T. Schäfer3, B. Sorg, C. Karalaib, E. Hecker* Deutsches Krebsforschungszentrum, Division Mechanisms of Tumorigenesis, Research Program 3, Risk Factors of Cancer and Cancer Prevention, Im Neuenheimer Feld 280, D-69009 Heidelberg, Germany Z. Naturforsch. 49b, 128-134 (1994); received September 6,1993 Daphnane Derivatives, Diterpene Esters, Simplexin, Skin Irritant Activity, Skin Tumor Promoting A...

dendrostellera lessertii (thymelaeaceae) is a toxic plant that grows in parts of iran. the anti-proliferative properties of its crude methanol extract and one of its active components, 3-hydrogenkwadaphnin (3-hk), have been established using several cancer cell lines. methods: in a further attempt to determine the mode of action, two groups of synchronously growing cells were treated with a sin...

Genkwa Flos (GF), the dried flower bud from Daphne genkwa Sieb. et Zucc. (Thymelaeaceae), is a well-known and widely used traditional Chinese medicine. However, we know little about the in vivo mechanism of GF toxicity. Nematode Caenorhabditis elegans has been considered as a useful toxicity assay system by offering a system best suited for asking the in vivo questions. In the present study, we...

Although the immense efforts have been made for cancer prevention, early diagnosis, and treatment, cancer morbidity and mortality has not been decreased during last forty years. Especially, lung cancer is top-ranked in cancer-associated human death. Therefore, effective strategy is strongly required for the management of lung cancer. In the present study, we found that novel daphnane diterpenoi...