The major goal of traditional platelet function tests has been to screen and diagnose patients who present with bleeding problems. However, as the central role of platelets implicated in the etiology of arterial thrombotic diseases such as myocardial infarction and stroke became widely known, platelet function tests are now being promoted to monitor the efficacy of antiplatelet drugs and also t...

The thrombotic response elicited by arterial injury or atherosclerosis varies widely between individuals; in some, diffuse coronary artery disease never triggers thrombotic occlusion, whereas others with limited disease experience myocardial infarction (MI) due to arterial thrombosis. Understanding the predictors for arterial thrombosis will improve tailored therapy for preventing and treating ...

Thrombotic complications are known as accepted feature of acute myeloid leukemia and tend to occur in patients with hyperleucocytosis. Acute myocardial infarction, though reported is a rare clinical presentation in patients with this subtype of leukemia. We describe an unusual case of acute myeloid leukemia in a patient with leucopenia presenting with an acute myocardial infarction. The possibl...

A simple technique for the reliable induction of coronary artery thrombosis in a conscious dog by delivery of low amperage electric current to the intimal surface of the artery io described. Ibuprofen, an agent known to inhibit platelet function and ptostaglandin synthesis is evaluated in this model. Comparison of myocardial infarct site, throabur weight, arrhythmia development and scanning ele...

Coronavirus disease 2019 (COVID-19) is a consequence of infection the upper and lower respiratory tract with severe acute syndrome coronavirus 2 but often becomes systemic disease, important involvement other organs. A bidirectional relationship exists between COVID-19 cardiovascular disease. On one hand, preexisting comorbidities, in particular high prevalence risk factors such as hypertension...

Cancer-associated thrombotic microangiopathy refers to a group of disorders characterised by microvascular thrombosis, thrombocytopenia, and ischaemic end-organ damage. Haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura are the two major subtypes. It can be a manifestation of the malignancy itself or a complication of its therapy. The addition of several new drugs to the therap...

In idiopathic thrombocytopenic purpura (ITP), a quite prevalent autoimmune hematological disease, thrombocytopenia is observed because of platelet destruction caused by immunological mechanisms. ITP usually leads to bleeding. Nevertheless, ITP, although rarely observed, may lead to thrombotic complications, including ischemic stroke. The present case is a female patient with ITP who developed c...

MYH9-related platelet disorders are inherited macrothrombocytopenias with additional clinical manifestations including renal failure, hearing loss, pre-senile cataract, and inclusion bodies in leucocytes that are present in different combinations. The MYH9 gene codes for the cytoplasmic contractile protein non-muscular myosin heavy chain IIA, present in several tissues. The bleeding tendency is...

The possible existence of distinctive, vascular bed specific alterations of coagulation and fibrinolytic parameters associated with three different types of thrombosis was investigated in young women (n = 68, <45 years at onset of the event) following myocardial infarction (MI) (n = 22), lacunar cerebral infarction (LACI) (n = 16), idiopathic deep vein thrombosis (VT) (n = 14) and venous thromb...