It is well known for Chikungunya fever to present as myriad of skin rash along with usual joint pain and fever, but probably this is the first case report of Chikungunya fever presenting as severe life threatening thrombotic microangiopathy, thrombotic thrombocytopenic purpura leading to multiple areas of skin necrosis, peripheral digital gangrene, haemolytic anemia, renal failure and severe th...

OBJECTIVE To describe a case with acute myocardial infarction caused by gastric carcinoma-associated thrombotic thrombocytopenic purpura. CLINICAL PRESENTATION AND INTERVENTION A 79-year-old man was admitted with abdominal pain and pyrexia. He later developed cardiac complications and microangiopathy that indicated worsening progression. Manifold evidence confirmed the diagnosis of myocardial...

Immune thrombocytopenic purpura is the most common autoimmune hematologic disease, affecting individuals of different ages. Recently, the bacterium Helicobacter pylori entered the list of causes of immune thrombocytopenic purpura. Here we present the case of a 55-year-old female patient with low platelet counts initially attributed to chronic vaginal bleeding. As corticosteroid therapy was inef...

A 50 year old male HIV patient on antiretroviral therapy was admitted for chest pain. Upon admission, the patient was found to have elevated cardiac enzymes, acute thrombocytopenia, hemolytic anemia, acute pancreatitis and acute renal failure. The patient was diagnosed with thrombotic thrombocytopenic purpura/haemolytic uremic syndrome and emergency plasma exchange therapy was initiated along w...

With the technical assistance of \Iiss MAuIIEEN JENNER T HERE IS now considerable evidence to suggest that the hemorrhagic manifestations of thrombocytopenic purpura and certain other disorders are probably due largely to deranged platelet function rather than to a reduction in platelet numbers. It is, of course, true that associated vascular changes also play an important role in thrombocytope...

the course of t he disorder is acute and chronic.the acute form o f the disease occurs most c ommonly in children , but is seen i n adults as well . the chronic recurrent f orm occurs most o f t e n in women between t wenty and forty years of age. we have studied 3000 cases from the patients o f hematological and internal department in imam khornaini medical ~~ntre , uni. of tehr an/ i ran. we ...