نتایج جستجو برای: thrombin like enzyme

تعداد نتایج: 890746  

Journal: :Blood 1993
C Krishnamurti C Bolan C A Colleton T M Reilly B M Alving

The role of defective fibrinolysis caused by elevated activity of plasminogen activator inhibitor-1 (PAI-1) in promoting fibrin deposition in vivo has not been well established. The present study compared the efficacy of thrombin or ancrod, a venom-derived enzyme that clots fibrinogen, to induce fibrin formation in rabbits with elevated PAI-1 levels. One set of male New Zealand rabbits received...

Journal: :Blood 1993
C G Binnie S T Lord

HE SERINE PROTEASE thrombin interacts with a T variety of substrates and as a consequence is involved in a number of physiologic processes. Fibrinogen is a particularly interesting substrate of thrombin for a number of reasons. First, thrombin cleaves not just one but four peptide bonds in fibrinogen, apparently in four successive steps. As a result ofthese proteolytic cleavages, the soluble fi...

2016
Mark R. Gillrie Bernard Renaux Eleanor Russell-Goldman Marion Avril Andrew J. Brazier Koichiro Mihara Enrico Di Cera Danny A. Milner Morley D. Hollenberg Joseph D. Smith May Ho

UNLABELLED Plasmodium falciparum malaria remains one of the most deadly infections worldwide. The pathogenesis of the infection results from the sequestration of infected erythrocytes (IRBC) in vital organs, including the brain, with resulting impairment of blood flow, hypoxia, and lactic acidosis. Sequestration occurs through the adhesion of IRBC to host receptors on microvascular endothelium ...

Journal: :pharmaceutical and biomedical research 0
himabindu reddy department of pharmacology and pharmacy practice, annamacharya college of pharmacy, rajampet, india chakka gopinath department of pharmacology and pharmacy practice, annamacharya college of pharmacy, rajampet, india mohamed saleem thattakudian sheikuduman department of pharmacology and pharmacy practice, annamacharya college of pharmacy, rajampet, india

thromboembolic disease is a common cause of morbidity and mortality. thrombin plays a key role in thrombotic events and thrombin inhibition represents a therapeutic event for thromboembolic events and has been identified as a target of therapy of its pivotal role in coagulation process. anticoagulation is a major intervention for the management of arterial and venous thromboembolic events. dabi...

Journal: :Thrombosis and haemostasis 2007
Karin Vretenbrant Sofia Ramström Maria Bjerke Tomas L Lindahl

Thrombin is a pivotal enzyme formed in the coagulation cascade and an important and potent platelet activator. The two protease-activated thrombin receptors on human platelets are denoted PAR1 and PAR4. The physiological relevance of PAR4 is still unclear, as both aggregation and secretion can be accomplished by PAR1 activation alone. In the present study we have investigated the role of PARs i...

2014
Heiko Rühl Lars Schröder Jens Müller Shorena Sukhitashvili Julia Welz Walther C. Kuhn Johannes Oldenburg Christian Rudlowski Bernd Pötzsch

INTRODUCTION The increased thrombotic risk of oral contraceptives (OC) has been attributed to various alterations of the hemostatic system, including acquired resistance to activated protein C (APC). To evaluate to what extent OC-associated APC resistance induces a prothrombotic state we monitored plasma levels of thrombin and molecular markers specific for thrombin formation in women starting ...

2002
Bernhard Güntert

We have analysed 15 infiltrating duct carcinomas of the breast, 10 gastrointestinal adenocarcinomas, one each of the thyroid and larynx, and four mesenchymal tumours for the presence and the nature of procoagulant activity (PCA). The metastatic tumours had a significantly higher PCA (P = 0.01-0.001) as compared to the non-metastatic tumours in the respective groups, and almost 20-25 times the a...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Zhiwei Chen Leslie A Pelc Enrico Di Cera

Prothrombin is the zymogen precursor of the clotting enzyme thrombin, which is generated by two sequential cleavages at R271 and R320 by the prothrombinase complex. The structure of prothrombin is currently unknown. Prethrombin-1 differs from prothrombin for the absence of 155 residues in the N-terminal domain and is composed of a single polypeptide chain containing fragment 2 (residues 156-271...

Journal: :Biochemistry 2005
Judith H Prieto Benedetta A Sampoli Benitez Giuseppe Melacini David A Johnson Matthew J Wood Elizabeth A Komives

Thrombomodulin (TM) forms a 1:1 complex with thrombin. Whereas thrombin alone cleaves fibrinogen to make the fibrin clot, the thrombin-TM complex cleaves protein C to initiate the anticoagulant pathway. The fourth and fifth EGF-like domains of TM together form the minimal fragment with anticoagulant cofactor activity. A short linker connects the fourth and fifth EGF-like domains of TM, and Met ...

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