Foxo transcription factors have a conserved role in the adaptation of cells and organisms to nutrient and growth factor availability. Here we show that Foxo1 has a crucial, nonredundant role in T cells. In naive T cells, Foxo1 controlled the expression of the adhesion molecule L-selectin, the chemokine receptor CCR7 and the transcription factor Klf2, and its deletion was sufficient to alter lym...

This article comments on the study by Schoenfeld, et al. entitled "The effect of protein timing on muscle strength and hypertrophy: a meta-analysis" and discusses how the methodology led to inconclusive results.

The Rockefeller University Press $30.00 J. Exp. Med. Vol. 206 No. 13 3101-3114 www.jem.org/cgi/doi/10.1084/jem.20091925 3101 The intestinal mucosa contains large numbers of mononuclear cells, including macrophages and DCs, which together are believed to play a central role in regulating mucosal innate and adaptive immune responses in both the steadystate and inflammatory setting (Kelsall, 2008)...

High-affinity antibodies are critical for host protection and underlie successful vaccines. The generation of such antibodies requires T cell–dependent help, which mediates germinal center reactions in which mutation and selection of B cells occurs. Using an interleukin 4–reporter system, we show here that CD4+ follicular helper T cells constituted essentially all of the cytokine-secreting T ce...