This review presents the evidence that supports the use of thioridazine (TZ) for the therapy of a pulmonary tuberculosis infection regardless of its antibiotic resistance status. The evidence consists of in vitro and ex vivo assays that demonstrate the activity of TZ against all encountered Mycobacterium tuberculosis (Mtb) regardless of its antibiotic resistance phenotype, as well as in vivo as...

The authors examined spectrophotometrically the ability of drugs to bind with ocular acid-insoluble melanin. Each drug, at 5 X 10(-5) M, was incubated at 37 degrees C for 8 hr with 4 mg of melanin in 20 mM potassium phosphate buffer (pH 7.4 and 8.0) or in 20 mM acetate buffer (pH 4.8). The authors findings showed that chloroquine, thioridazine, befunolol, pindolol, daunomycin, and 5-fluorouraci...

Abstract Background Melanoma shows increasing incidence and has the highest propensity to metastasize brain of all primary malignant tumors. Untreated, median survival time is 2-3 months after diagnosis, while aggressive treatment extends only 4-12 months. Even though targeted therapies immunotherapy changed therapeutic landscape, many these patient relapse. In this respect, drug repurposing, u...