This paper concerns several animal models for study of pathogenic mechanisms in mycoplasma infection. Although these will seem remote from the general topic of this symposium, it is conceivable that some of the mechanisms may have implications for chronic pulmonary disease. Mycoplasmas are known to be causative agents in acute and chronic pulmonary infections in several species of domestic anim...

to confirm the side-effects of gold sodium thiomalate (gstm), we carried out a retrospective study examining 102 consecutive patients with rheumatoid arthritis attending the rheumatology unit of hafez hospital, shiraz, iran, in whom gstm was initiated between 1983-1989. only patients with classical or definite ra (ara criteria) we(e included in this study. patients were categorized as having de...

Formation of granuloma and production of antibodies in guinea-pigs receiving egg albumen with Freund's adjuvant may be suppressed by cortisone (Fischel, Kabat, Stoerk, Skolnick, and Bezer, 1954). The arthritis induced in rats by Freund's adjuvant may also be prevented by treatment with cortisone (e.g. Houssay and Frangione, 1961; Pearson, Wood, and Waksman, 1961), pyrazolidines, salicylates, an...

During the period 1971-1979, 114 patients with rheumatoid arthritis attending the arthritis clinics at Groote Schuur Hospital and Princess Alice Orthopaedic Hospital were treated with gold sodium aurothiomalate (Myocrisin). Data obtained from 104 completed protocols showed that 70 patients (67,3%) benefited from chrysotherapy. Forty of these patients went into complete remission. Therapy was di...

The granule fraction of human leukocytes contains neutral protease capable of degrading the noncollagenous protein mucopolysaccharide matrix of cartilage at neutral pH in physiological salt solution. Cartilage degradation was monitored by quantitating the release of (35)S from labeled rabbit ear cartilage. Degradation of cartilage matrix occurs when intact viable human leukocytes are incubated ...

OBJECTIVE To assess the efficacy and safety of sulfasalazine (SSZ) compared to placebo and other disease modifying drugs. METHODS A metaanalysis was performed on 15 randomized clinical trials of rheumatoid arthritis (RA) that included SSZ (2 g/day average dose, 36 weeks average followup) as a treatment. Eight trials included a placebo group (PL), 2 hydroxychloroquine (HCQ) (350 mg/day average...

We have determined the framework structure of Myochrysine (disodium gold(I)thiomalate) in the solid state and extremely concentrated aqueous solution, previously. It consists of an open chain polymer with linear gold coordination to two thiolates from the thiomalic acid moieties which bridge between pairs of gold atoms providing an Au-S-Au angle of 95 degrees . The question remained: was this s...

A new self-assembly nanoprobe, mercaptoethylamine-modified-gold nanoparticles-Lysine-bridged-bis(β-cyclodextrins)-fluorescein (MGNPs-Lys-bis(β-CDs)-FL), based on fluorescence resonance energy transfer (FRET) was developed for determination of trypsin firstly in biological systems. With the Lys-bis(β-CDs)-FL complex as an energy donor and mercaptoethylamine (MEA)-modified gold nanoparticles (MGN...

Medically compromised patients with disordered eating are admitted to the childrens ward of the Gold Coast University Hospital following a treatment protocol, including immediate insertion of nasogastic tube and commencement of enteral feeding, which is independent of admitting diagnosis, including anorexia nervosa, eating disorder not otherwise specified, anxiety and mood disorders. Data has b...