Controlling the bio-inspired redox conversion of Co(II)–disulfide compounds to their related Co(III)–thiolate complexes is a perplexing task as factors triggering this reaction are not fully understood. Three disulfide ligands 2,2?–disulfanediylbis(N,N-bis((3,5–dimethyl-1H–pyrazol–1–yl)methyl)ethan-1-amine) (LmpzSSLmpz), 3,3?-disulfanedylbis(N,N-bis(pyridin-2-ylmethyl)propan-1-amine) (LpSSLp), ...

Bacillus subtilis encodes redox-sensing MarR-type regulators of the OhrR and DUF24-families that sense organic hydroperoxides, diamide, quinones or aldehydes via thiol-based redox-switches. In this article, we characterize the novel redox-sensing MarR/DUF24-family regulator HypR (YybR) that is activated by disulphide stress caused by diamide and NaOCl in B. subtilis. HypR controls positively a ...

Cyanoacrylate thiolate salts such as the sodium salt o f ethoxyethyl-3-/?-chlorobenzylthio2-cyano-3-m ercapto acrylate have been shown to be relatively slow binding, po ten t inhibitors o f photosynthetic electron transport, th a t are equally active against thylakoids isolated from atrazine-susceptible and atrazine-resistant Brassica napus seedlings. It has been suggested tha t their m ode o f...

The coordinative chemistry of the tridentate thiosemicarbazone ligand 2-pyridinecarboxaldehyde 4-N-ethylthiosemicarbazone (HL(Et)) has been explored by using an electrochemical methodology. All the complexes have been characterized using analytical and spectroscopic techniques. In the case of copper we have isolated two different complexes, with Cu(L(Et))(2).4H(2)O (6) and [Cu(2)(L(Et))(2)(SO(4...

We report a high yielding synthesis of truly monodisperse, thiolate-protected silver clusters via a rationally designed approach. The cluster composition was determined by electrospray ionization (ESI) mass spectrometry to be Ag(7)(DMSA)(4), where DMSA represents meso-2,3-dimercaptosuccinic acid. The Ag(7) thiolate clusters exhibit distinct optical properties. The approach developed in this wor...

High affinity thiolate-based polymeric capping ligands are known to impart stability onto nanosized gold nanoparticles. Due to the stable gold-sulfur bond, the ligand forms a protective layer around the gold core and subsequently controls the physicochemical properties of the resultant nanogold mononuclear protected clusters (AuMPCs). The choice of ligands to use as surfactants for AuMPCs large...

Glycolytic interconversion of phosphoglycerate isomers is catalysed in numerous pathogenic microorganisms by a cofactor-independent mutase (iPGM) structurally distinct from the mammalian cofactor-dependent (dPGM) isozyme. The iPGM active site dynamically assembles through substrate-triggered movement of phosphatase and transferase domains creating a solvent inaccessible cavity. Here we identify...

All known nitrogenase cofactors are rich in both sulfur and iron and are presumed capable of binding and reducing N2. Nonetheless, synthetic examples of transition metal model complexes that bind N2 and also feature sulfur donor ligands remain scarce. We report herein an unusual series of low-valent diiron complexes featuring thiolate and dinitrogen ligands. A new binucleating ligand scaffold i...