Aging and reduced longevity are due in part to the action of free radicals (FR). Melatonin (Mel) and thioctic acid (TA) are effective in protecting against the damage caused by FR. In this study, the effect of Mel and TA on the life cycle of Drosophila melanogaster was determined. We used a control group of flies, another group that was provided with Mel (0.43 mM) throughout their life cycle (M...

The article presents current data from the scientific medical literature on effective use of R(+)-enantiomer α-lipoic acid in various pathological conditions. authors analyze comparative assessment activity racemic and dextrorotatory forms thioctic (alpha-lipoic) low back pain, effect combination with hyperbaric oxygen therapy production interleukin-6, tumor necrosis factor α vascular endotheli...

In 1957, Morton et at. (1) isolated a substance having the absorption maxima at 272 and 400 mƒÊ using paper chromatography from the lipid fraction of rat liver, and found that the hepatic content of this substance increased remarkably in the rats with vitamin A deficiency. Isler et at. (2) established the molecular structure of the compound including quinone nucleus with similar absorption char...

EVIDENCE-BASED GUIDELINE UPDATE: NSAIDs AND OTHER COMPLEMENTARY TREATMENTS FOR EPISODIC MIGRAINE PREVENTION IN ADULTS: REPORT OF THE QUALITY STANDARDS SUBCOMMITTEE OF THE AMERICAN ACADEMY OF NEUROLOGY AND THE AMERICAN HEADACHE SOCIETY Larry Charleston IV, Grand Rapids, MI: Holland et al.1 highlighted the evidence of complementary treatments for the prevention of episodic migraine. There are a f...

Chronic inflammation of the hair follicle (HF) is considered a contributing factor in the pathogenesis of androgenetic alopecia (AGA). Previously, we clinically tested liposterolic extract of Serenoa repens (LSESr) and its glycoside, β-sitosterol, in subjects with AGA and showed a highly positive response to treatment. In this study, we sought to determine whether blockade of inflammation using...

Solid core polymeric particles are an attractive delivery vehicle as they can efficiently encapsulate drugs of different physical and chemical characteristics. However, the effective targeting of such particles for therapeutic purposes has been somewhat elusive. Here, we report novel polymeric particles comprised of poly(lactic acid) (PLA) with incorporated poly(ethylene glycol)-lipids (PEG-lip...

α-Lipoic acid (6,8-thioctic acid; LA) is a vital co-factor of α-ketoacid dehydrogenase complexes and the glycine cleavage system. In recent years it was shown that biosynthesis and salvage of LA in Plasmodium are necessary for the parasites to complete their complex life cycle. LA salvage requires two lipoic acid protein ligases (LplA1 and LplA2). LplA1 is confined to the mitochondrion while Lp...