نتایج جستجو برای: thiazolo 3
تعداد نتایج: 1811556 فیلتر نتایج به سال:
In the title mol-ecule, C20H22N2O4S, the pyrimidine ring is in a flattened half-chair conformation and the 3-meth-oxyphenyl substituent is in an axial arrangement. The thia-zole ring forms a dihedral angle of 81.3 (1)° with the benzene ring. In the crystal, weak C-H⋯S inter-actions link mol-ecules into chains along [001]. In addition, there are π-π inter-actions between inversion-related thia-z...
BACKGROUND The derivatives of thieno[2,3-b]thiophene belong to a significant category of heterocyclic compounds, which have shown a wide spectrum of medical and industrial application. RESULTS A new building block with two electrophilic center of thieno[2,3-b]thiophene derivatives 2 has been reported by one-pot reaction of diketone derivative 1 with Br2/AcOH in excellent yield. A variety of h...
An effective method of synthesis thiazolo[3,2-a]pyrimidine derivatives was developed and the compounds with n-pentyl or β-acetoxycyclopropyl as well fluorescent benzo[f]coumarin substituents were obtained yields 60 % more. Using computational (in silico) approaches we demonstrated ability to permeate lipid bilayer their affinity some protein kinases (compounds 4 6 bind a kinase AKT1 PDB code 3о...
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