A pot experiment was conducted to evaluate the effect of foliar spray of salicylic acid (0, 50, 100 ppm), ascorbic acid (0, 100, 200 ppm) and thiamine (0, 50, 100 ppm) on vegetative growth, flowering and photosynthetic pigments of marigold (Calendula officinalis L.) plants at greenhouse of SB University of Kerman, Iran. Results showed that application of salicylic acid and thiamine inc...

Although thiamine has been known and studied for many years, there is still much we do not know about its physiological functions and mechanism of action in biological systems, particularly in animal tissues. Earlier workers have shown that thiamine diphosphate (cocarboxylase) functions as a coenzyme in the metabolism of pyruvate and a-ketoglutarate (l-9). However, the question regarding the im...

BACKGROUND Thiamine metabolites and activities of thiamine-dependent enzymes are impaired in Alzheimer's disease (AD). OBJECTIVE To clarify the mechanism for the reduction of thiamine diphosphate (TDP), an active form of thiamine and critical coenzyme of glucose metabolism, in AD. METHODS Forty-five AD patients clinically diagnosed and 38 age- and gender-matched control subjects without dem...

Thiamine (Vitamin B1) is an essential vitamin that must be obtained from the diet for proper neurological function. At higher doses, thiamine and benfotiamine (S-benzoylthiamine O-monophosphate, BT)-a phosphorylated derivative of thiamine-have antinociceptive effects in animals and humans, although how these compounds inhibit pain is unknown. Here, we found that Prostatic acid phosphatase (PAP,...

This study examined the role of sulfur (S) in the pathogenesis of S-induced polioencephalomalacia (PEM) in beef cattle in the context of thiamine status and metabolism. Thiamine, thiamine monophosphate (TMP) and thiamine pyrophosphate (TPP) status in rumen fluid, blood and brain tissue were determined in beef heifers fed 2 levels of S [low S (LS) vs. high S (HS)] at 2 forage-to-concentrate rati...

quate intake of thiamine or consumption of food containing anti-thiamine factors (ATF). As sociation with other pathologic conditions such as alcoholism or liver diseases has also been reported (1). In Thailand, thiamine deficiency is reported that high in the northern and northeastern provinces (2). By determining the thiamine pyrophosphate effect (TPPE), in 21.6% of ill northern Thai subjects...

Thiamine was found to be accumulated in protoplasts of Saccharomyces cerevisiae in the same manner as in intact cells, suggesting that a soluble thiamine-binding protein in periplasm may not be an essential component of the thiamine transport system of S. cerevisiae. It was also found that thiamine pyrophosphate cannot be taken up by yeast protoplasts.

Parkinson's disease (PD) is a systemic disease with motor and non-motor deficits. We recruited three patients with newly diagnosed PD. They were not under anti-Parkinson's therapy. Plasmatic thiamine was within healthy reference range. We performed the Unified Parkinson's Disease Rating Scale (UPDRS) and started a parenteral therapy with high doses of thiamine. The therapy led to a considerable...

We found that CPY production in Saccharomyces cerevisiae KS58-2D/pCY303 was increased by the addition of thiamine into the medium, while the addition of thiamine had no effect on cell growth. It became clear that the positive effect of thiamine was due to transcriptional increase, because the levels of CPYmRNA were increased according to the amount of thiamine added. Furthermore, it was suggest...