Microvesicles are cell-derived signaling particles emerging as important mediators and biomarkers of systemic inflammation, but their production in severe burn injury patients has not been described. In this pilot investigation, we measured circulating microvesicle levels following severe burns, with severe sepsis patients as a comparator group. We hypothesized that levels of circulating vascul...

A burn injury is one of the most severe forms of trauma that can be sustained (National Burn Care Review Committee Report [NBCR], 2001). Burns and scalds can have a wide variety of causes such as thermal, mechanical, chemical, electrical or radiation, but all will involve coagulative destruction of the skin (Rawlins, 2011). About 250,000 people sustain burn injuries in the UK every year; 175,00...

BACKGROUND An understanding of prognosis following burns is important. It alleviates patient and familial stress, provides a framework for better resource use, and facilitates benchmarking of performance between specialist centers. METHODS Data were collected from eight tertiary referral burns centers in Australia and New Zealand. Our aim was to identify factors independently associated with ...

Post-burn cervical contractures are the consequence of deep burns, which are often neglected or badly managed. They affect the patients' general functioning, aesthetic appearance, and psychological state of mind, and treatment can be difficult. We conducted a retrospective study that lasted six years (January 2002-January 2008), analysing epidemiological and clinical features as well as the ind...

The aim of this study was to determine the demographic characteristics of burnt children in need of hospitalization, causes of burns and associated complications in Fars province, Iran. This is a retrospective cross-sectional study. Files of all children under 15 years of age who were hospitalized in the only burn referral centre of Fars province were evaluated. Data regarding age, gender, loca...

The present work analyzes scald burns from hot beverages, such as coffee and tea, spilled on the lap, i.e., an incident that may occur in daily life. The Pennes bioheat equation is solved numerically for small spills wetting the clothing, i.e., the fabric prevents the spilled liquid from draining away. Temperatures are analyzed in the wetted fabric and the skin layers and the resulting skin inj...

BACKGROUND Microalbuminuria, often referred to as the urinary albumin-creatinine ratio (ACR), is thought to be a reflection of increased capillary permeability associated with the systemic inflammatory response syndrome, and has been found to be predictive of outcome in several studies. Therefore, we explored the usefulness of ACR as a predictor of mortality, and whether there was a correlation...

Burn injuries are a devastating critical care problem. In children, burns continue to be a major epidemiologic problem around the globe resulting in significant morbidity and death. Apparently, treating these burn injuries in children and adults remains similar, but there are significant physiological and psychological differences. The dermal layer of the skin is generally thinner in neonates, ...

Introduction Infection was recognized by some 19th and early 20th century workers to be an important and potentially lethal complication of severe burns (Lustgarten, 1891; Stockis, 1903). The bacterial flora of burns were studied by Pack (1926), Aldrich (1933), Cruickshank (1935), Colebrook, Duncan & Ross (1948) and others before and during the second World War, but their pathogenic importance ...

It is generally agreed that thermal injury in patients and experimental animals may be associated with a variety of immunological abnormalities (1). Burned subjects have been shown to accord prolonged survival times to skin allografts (2), and this change has been associated with a diminution of their ability to exhibit delayed hypersensitivity reactions (3). In addition, the studies of Rosenth...