abstract accumulation of gene changes and chromosomal instability in response to cellular dna damage lead to cancer. dna damage induces cell cycle checkpoints pathways. checkpoints regulate dna replication and cell cycle progression, chromatin restructuring, and apoptosis. checkpoint kinase 2 (chk2) is activated in response to dna lesions. atm phosphorylate chk2. the activated chk2 kinase can p...

allergic rhinitis (ar) is one of the most common chronic diseases in the developed countries. this study was performed to investigate the effect of cpg-odn in alteration of t-helper (th)1/th2 balance of patients with ar treated with intranasal corticosteroids (incs) and antihistamines. peripheral blood mononuclear cells (pbmcs) of 20 patients with ar were isolated before and after 45 days thera...