Trade-off reviews the rate of marginal substitution of inputs and outputs onto the efficient frontier. On the other hand, marginal rates of substitution (MRS) are important quantities for analysts and managers. In this paper, by changing the method of Asmild (2004), an algorithm is found that it can be used to calculate the marginal rate of the free disposal hull (FDH) model.

The issue of the generic versus brand-name drug inter-changeability is an intensely debated theme historically focused on whether bioequivalence testing can guarantee therapeutic efficacy. The controversy is supported by reports of the lack of therapeutic equivalence between some generic medicinal products and brand-name drugs, as well as by a great deal of editorials expressing a negative view...

Lexical substitution is a task of determining a meaning-preserving replacement for a word in context. We report on a preliminary study of this task for the Croatian language on a small-scale lexical sample dataset, manually annotated using three different annotation schemes. We compare the annotations, analyze the inter-annotator agreement, and observe a number of interesting language-specific ...

Trace caches deliver a high number of instructions per cycle to wide-issue superscalar processors. To overcome complex control flow, multiple branch predictors have to predict up to 3 conditional branches per cycle. These multiple branch predictors sometimes predict completely wrong paths of execution, degrading the average fetch bandwidth. This paper shows that such mispredictions can be detec...

It is well known that, given an endofunctor H on a category C, the initial (A+H−)-algebras (if existing), i.e., the algebras of (wellfounded) H-terms over different variable supplies A, give rise to a monad with substitution as the extension operation (the free monad induced by the functor H). Moss [17] and Aczel, Adámek, Milius and Velebil [2] have shown that a similar monad, which even enjoys...

Oligomerization of the amyloid β-protein (Aβ) is a seminal event in Alzheimer's disease. Aβ42, which is only two amino acids longer than Aβ40, is particularly pathogenic. Why this is so has not been elucidated fully. We report here results of computational and experimental studies revealing a C-terminal turn at Val36-Gly37 in Aβ42 that is not present in Aβ40. The dihedral angles of residues 36 ...

Generic immunosuppressive drugs are available in Europe, Canada, and the United States. Between countries, there are large differences in the market penetration of generic drugs in general, and for immunosuppressive drugs in particular. The registration criteria for generic immunosuppressive drugs are often criticized. However, it is unlikely that the criteria for registration of narrow therape...