Lymphatic vessels maintain tissue fluid homeostasis by returning to blood circulation interstitial that has extravasated from the capillaries. They provide a trafficking route for cells of immune system, thus critically contributing surveillance. Developmental or functional defects in lymphatic vessels, their obstruction damage, lead accumulation tissues, resulting lymphedema. Here we discuss d...

The Kirsten rat sarcoma viral oncogene homolog (KRAS) is mutated in approximately 25% of all human cancers and known to be a major player promoting maintaining tumorigenesis through the RAS/MAPK pathway. Over years, large number studies have identified strategies at different regulatory levels tackle this ‘difficult-to-target’ oncoprotein. Yet, most ideal strategy overcome KRAS its downstream e...