Intimates regularly confront their partners to motivate them to change undesirable behaviors. Nevertheless, contextual perspectives suggest that qualities of the partner may determine the implications of such attempts. Consistent with these ideas, a pilot study of romantic relationships, an observational study of newlyweds, and a diary study of married couples demonstrated that partner depressi...

In response to concerns about inappropriate testing and healthcare costs, clinicians and laboratorians should work together to evaluate laboratory tests. Studies of routine laboratory tests ordered for screening and case-finding in the preoperative setting, at hospital admission, and in the ambulatory setting have not provided sufficient evidence of the benefits of case-finding when evaluated a...

The use of antibody-drug conjugates (ADCs) as a therapeutic platform to treat cancer has recently gained substantial momentum. This therapeutic modality has the potential to increase the efficacy and reduce the systemic toxicity associated with current therapeutic regimens. The efficacy of ADCs, however, relies on the proper exploitation of intracellular sorting dynamics of the antigen as well ...

ayurveda, manoeuvres mankind to head a healthy life in order to pursue four-fold bliss. with a view to combat physical and mental annoyances, classics have explicated two-fold therapeutic modalities; langhana/depletion and brihmana/nourishing. upavasa /fasting is one among ten depletion therapies explained. it is envisioned at all three levels of ayurvedic therapies- rational/objectively planne...

Immunoadjuvants play a key role in enhancing the efficacy of therapeutic tumor vaccines for treating malignant and recurrent cancers. However, due to bottleneck rational design mechanistic...

This research examined the relative effects of other-efficacy and self-efficacy beliefs in relation to individual performance within a cooperative dyadic setting. Pairs of female participants (M(age) = 20.08, SD = 1.93) performed three practice trials on a dyadic dance-based videogame. Other-efficacy and self-efficacy beliefs were then manipulated through the provision of bogus feedback regardi...

cardiovascular diseases are the most common causes of human morbidity and mortality despite significant therapeutic improvements by surgical or pharmacological approaches in the last decade. micrornas (mirnas) have a significant role in diseases development or response to treatment. in this review, we summarized the role of mirnas in the pathogenesis or the treatment of coronary artery disease ...

BACKGROUND AND AIM Mucosal healing in inflammatory bowel disease (IBD) can be achieved by improvement of intestinal barrier protection. Activation of hypoxia-inducible factor (HIF) has been identified as a critical factor for barrier protection during mucosal insult and is linked with improvement in symptoms of colitis. Although prophylactic efficacy of HIF hydroxylase inhibitors in murine coli...

Background: Melasma is a brown or grayish brown symmetrical facial hyperpigmentation.A number of medicamens can be used for the treatment of this condition. For better results in treating melasma, combination therapy is preferred. The aim of this study was to determine the clinical efficacy and adverse effects of azelaic acid 20% plus hydroquinone 5% versus hydroquinone 5% alone in the manageme...