Abstract The main aim of this study was to prepare and evaluate the extended - release system of an anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studies focused on the development of extended drug delivery system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and polyvinylpyrrolidone (PVP k30...

This section expands on the analysis of Section 3 in the original manuscript regarding the relation of the SHGP to Hierarchical Gamma (HGP) and Hierarchical Dirichlet processes (HDP) as seen in Table 1. The SHGP is a prior over the weight matrix J as opposed to the HDP which is a prior over the transition matrix P . This difference is crucial, since it allows for direct manipulation of the weig...

A conditional spatial autoregression (CAR) specifies dependence via a weight matrix. Employing a doubly stochastic weight matrix allows users to interpret the CAR prediction rule as a semiparametric prediction rule and as BLUP with smoothing in addition to other benefits. We examine standard and doubly stochastic weight matrices in the context of an illustrative data set to demonstrate feasibil...

The organic matrix from normal and pimpled calcified chicken eggshells were dissociated into acid-insoluble, water-insoluble, and facultative-soluble (both acid- and water-soluble) components, to understand the influence of shell matrix on eggshell qualities. A linear correlation was shown among these 3 matrix components in normal eggshells but was not observed in pimpled eggshells. In pimpled ...

This paper develops two new models and evaluates the impact of using different weight matrices on parameter estimates and inference in three distinct spatial specifications for discrete response. These specifications rely on a conventional, sparse, inverse-distance weight matrix for a spatial auto-regressive probit (SARP), a spatial autoregressive approach where the weight matrix

This equation may be viewed as reducing the sum of n terms of the power sequence to a linear combination of the first r + 1 terms. Accordingly, there is an implicit assumption that n > v. Note that the matrix appearing as the middle factor on the right side of this equation is lower triangular. The zeros that should appear above the main diagonal have been omitted. The nonzero entries constitut...