Superoxide dismutase (SOD) catalyzes the conversion of superoxide radical to hydrogen peroxide. Periplasmic localization of bacterial Cu,Zn-SOD has suggested a role of this enzyme in defense against extracellular phagocyte-derived reactive oxygen species. Sequence analysis of regions flanking the Salmonella typhimurium sodC gene encoding Cu,Zn-SOD demonstrates significant homology to lambda pha...

background: we aimed at evaluating the toxicity effects of low (subtoxic) concentrations of silver nanoparticles (agnp, 5-10 nm) in human hepatoblastoma (hepg2) cell line after and during a period of about one month. methods: xtt and mtt assays were used to draw a dose-response curve ic50 (half maximal inhibitory concentration) value of the agnp on hepg2 cells was calculated to be 2.75-3.0 mg/l...

Down syndrome or trisomy 21 is the single most common genetic cause of mental retardation. It has been postulated that there is oxidative stress in Down syndrome due to over expression of superoxide dismutase 1 (SOD -1) , an antioxidant enzyme which is coded on chromosome 21(21q22.1). The present study included 31 clinically diagnosed children with Down syndrome. The diagnosis of trisomy 21 was...

Cells devoid of cytosolic superoxide dismutase (SOD) suffer enzyme inactivation, growth deficiencies, and DNA damage. It has been proposed that the scant superoxide (O2-) generated by aerobic metabolism harms even cells that contain abundant SOD. However, this idea has been difficult to test. To determine the amount of O2- that is needed to cause these defects, we modulated the O2- concentratio...

Objective(s): to investigate the chronopharmacological effects of growth hormone on executive function and the oxidative stress response in rats. Materials and Methods: Fifty male Wistar rats (36-40 weeks old) had ad libitum access to water and food and were separated into four groups: diurnal control, nocturnal control, diurnal GH-treated, and nocturnal GH-treated animals. Levels of Cu, Zn sup...

INTRODUCTION Superoxide dismutase (SOD) is one of the most important antioxidant enzymes present in all oxygen-metabolizing cells. This enzyme eliminates toxins from our body, so it is vital to understand its action and activity under the influence of different wavelengths. The effects of different wavelengths of light in the visible range on SOD activity were investigated. METHODS Enzyme sam...

Background: Blindness due to cataract is a major and important problem in Pakistan. The problem is expected to increase in future due to increase in tobacco smoking. The aim of study was to look for the mechanism associated with metal deposition and its effect on antioxidant enzymes in lens of smokers in Karachi, Pakistan. Methods: 20 cataract patients were randomly selected from Out Patient De...

this study was conducted on two canola (brassica napus) cultivars, okapi a winter type and cold tolerant and rgs003 a spring type and cold sensitive. seedlings were grown in an environmentally controlled growth room with 16 h d-1 photoperiod at 22/16 °c (day/night, control). at the 4-leaf stage, half of pots were transferred to a cold growth room for 7 d at 10/3°c (day/night, cold treatment) an...