نتایج جستجو برای: thalassemic patients
تعداد نتایج: 2085514 فیلتر نتایج به سال:
background: thalassemic disorders are the most prevalent monogenic hereditary diseases around the world caused by decreased and altered synthesis or agenesis in one or more globin chains. families who have a child with thalassemia major face a myriad of significant problems. hormozgan province ranks second with thalassemic patients in iran. therefore, current research is aimed to analyze the re...
Preclinical and clinical studies demonstrate the feasibility of treating β-thalassemia and Sickle Cell Disease (SCD) by lentiviral-mediated transfer of the human β-globin gene. However, previous studies have not addressed whether the ability of lentiviral vectors to increase hemoglobin synthesis might vary in different patients.We generated lentiviral vectors carrying the human β-globin gene wi...
Introduction: The coagulation factor 13 has a fundamental role in homeostasis, protective effects on thrombosis, and some other associated diseases. Due to increasing the chronic coagulability of major thalassemic patients, this study was conducted with aim determining the prevalence of Val34LeuFXIII polymorphism in the thalassemic patients. Materials and methods: The present case-control stud...
introduction: the study was conducted to assess the school activity of thalassemic children and to reveal the relationship between school activity with the socio-demographic factors as well as clinico-therapeutic profile. methods: a total of 365 admitted thalassemic patients of burdwan medical college (ages 5 to 12 years) were participated in this cross sectional descriptive study conducted on ...
Background and Objectives. In non-thalassaemic women serum erythropoietin (Epo) level increases during pregnancy, whereas that of soluble transferrin receptor (STFR) drops slightly in the first two trimesters to attain the original values in the third trimester. In this study the time-course of these two parameters was explored in β-thalassemic and nonβ-thalassemic women, both pregnant and not.
Hypothyroidism is an important endocrine complication of major thalassemia. It should be prevented because of its effects on patients’ growth and development. The aim of this study was to determine the effect of regular blood transfusion and desferal use in preventing of such complications. An observational, cross-sectional study was conducted on 185 major thalassemic adolescents in Hazrat Al...
background: approximately 180 mutations have been described in β-thalassemia worldwide with specific spectrum in each ethnic population. this study determines the spectrum and the frequency of β-thalassemia mutations in patients with β-thalassemia trait and sickle cell-β-thalassemia. methods: fifteen compound heterozygous sickle cell thalassemia (sct) and 23 β-thalassemia trait patients were ...
Neutrophil chemotactic and functional defects occur in beta-thalassemia and in patients after bone marrow transplantation (BMT). Interleukin-8 (IL-8) is a novel chemotactic and activating peptide for neutrophils and can be detected in the circulation. IL-8 serum concentrations were evaluated in 30 beta-thalassemic patients before and after BMT. Serial samples from 16 patients were also studied....
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