نتایج جستجو برای: th2
تعداد نتایج: 13223 فیلتر نتایج به سال:
Although Bach2 has an important role in regulating the Th2-type immune response, the underlying molecular mechanisms remain unclear. We herein demonstrate that Bach2 associates with Batf and binds to the regulatory regions of the Th2 cytokine gene loci. The Bach2-Batf complex antagonizes the recruitment of the Batf-Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production. Furthermore,...
T1/ST2, an orphan receptor with homology with the interleukin (IL)-1 receptor family, is expressed constitutively and stably on the surface of T helper type 2 (Th2) cells, but not on Th1 cells. T1/ST2 is also expressed on mast cells, which are critical for Th2-mediated effector responses. To evaluate whether T1/ST2 is required for Th2 responses and mast cell function, we have generated T1/ST2-d...
We previously showed that the amounts of Fyn protein in Th2 clones were approximately one-third to one-fifth of those in Th1 clones. In this study we examined the role of Fyn in the polarization of naive CD4+ T cells toward the Th2 subset using fyn(-/-) mice. The fyn(-/-) naive CD4+ T cells efficiently produced Th2 cytokines and polarized toward the Th2 subset even in the absence of IL-4 and IL...
چکیده زمینه و هدف: مولتیپل اسکلروزیس(ms) یک بیماری خودایمن سیستم اعصاب مرکزی است. اگرچه سلول های متعددی مانند سلول های b ، cd8+ t، میکروگلیا/ماکروفاژ، دندریتیک، آستروسیت و ماست سل در پاتوژنز بیماری ms نقش دارند، ولی به نظر می رسد که سلول های خود واکنش گر t cd4+ اختصاصی میلین، نقش مهمتری در پاتوژنز این بیماری دارند. در این مقاله یافته های اخیر در مورد نقش زیرگروه های سلول های t در پاتوژنز بیماری...
estrogens foster immunological processes driven by cd4+ th2 cells and b cells and androgens foster th1 cd4+ and cd8+ cell activity. higher levels of ifn-gamma and il-2 and lower levels of il-4 and il-10 are detected in the phytohemagglutinin-stimulated lymphocyte culture supernatants of men compared with women. it is documented that the physiologic levels of estrogens produced during the luteal...
is the production of IL-12 by macrophages and dendritic cells responding to antigens or direct infection immune response; transplantation [3]. Polarized Th1 cells produce IL-2, IFN-c, and lymphotoxin. These cytokines promote the development of cytotoxic T cells, which support delayed-type hypersensitivity reaction (DTH) and facilitate anti-body-dependent cellular cytotoxicity (ADCC) serving Twe...
We showed that dietary long-chain (n-3) PUFAs present in fish oil (FO) affect CD4(+) T cell proliferation and cytokine production in C57BL/6 mice. To test the hypothesis that the anti-inflammatory effect of dietary (n-3) PUFAs could be due to the indirect suppression of T helper (Th)1 cells by cross-regulation of enhanced Th2 activation, mice were fed a wash-out control diet [5% corn oil (CO), ...
Background and Objectives: Over-production of the type II T-helper cells (Th2-shfit) has been suggested as a candidate mechanism for the etiology in at least one subgroup of schizophrenia. Hitherto, empirical evidence is derived mostly from in vitro cytokine production. Due to frequently undetectable serum levels of the major Th2 cytokine Interleukin-4 (IL-4), direct evidence, measured as a rat...
Using a Schistosoma mansoni egg-induced granuloma model, we examined the ability of CpG oligodeoxynucleotides (ODN) to suppress Th2-type cytokine expression and to prophylactically immunize against Th2-dependent pulmonary pathology. The mechanism was examined by studying Th2 response regulation in cytokine-deficient mice. Surprisingly, our findings revealed several functions of CpG DNA that wer...
background: th1 cells preferentially express cxcr3, ccr5 and ccr6, while ccr3 and ccr4 are predominantly expressed by th2 cell subsets. multiple sclerosis (ms) is a th1 cell-dependant chronic inflammatory disease of the central nervous system, and immunomudolatory cytokines could alter the chemokine expression pattern of these lymphocyte subsets. objective: this study was performed to measure c...
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