BACKGROUND Surfactant proteins (SPs) have been described in various tissues and fluids including tissues of the nasolacrimal apparatus, airways and digestive tract. Human testis have a glandular function as a part of the reproductive and the endocrine system, but no data are available on SPs in human testis and prostate under healthy and pathologic conditions. OBJECTIVE The aim of the study w...

The worldwide occurrence of cyanobacterial blooms due to water eutrophication evokes extreme concerns. These blooms produce cyanotoxins which are hazardous to living organisms. So far among these toxins, Microcystin-LR (MC-LR) is the most toxic and the most frequently encountered toxin produced by the cyanobacteria in the contaminated aquatic environment. Microcystin-LR is a potential carcinoge...

In recent years it has repeatedly demonstrated by a number of investigators in various animal species that a single administration of cadmium salt produces a selective damage to the testis (in mice, Meek 1959, Chiquoine 1964; in rats, Pati.zek and Zâhot 1956, Allanson and Deanesly 1962, Kar and Das 1962, Gunn, Gould and Anderson 1961, 1963a,b, Mason, Brown, Young and Nesbit 1964 ; in rabbits, C...

Correspondence to: Dolores Mruk and C. Yan Cheng; Email: [email protected] and [email protected] Contaminants such as cadmium, bisphenol A and lead pollute our environment and affect male reproductive function. There is evidence that toxicant exposure adversely affects fertility. Cadmium and bisphenol A exert their effects in the testis by perturbing bloodtestis barrier funct...

Introduction: In laser surgery, the laser beam can evaporate and cut the tissue like a small surgical knife when the tissue temperature is heated to 100 degrees Celsius. a complete understanding of the distribution of damage in both pathologic tissue and surrounding tissue is necessary. Although the test is the most realistic solution for treating medical problems, for this rea...

The aim of the study is to examine the role of matrix metalloproteinases (MMPs) and their inhibitors (TIMP) during testicular ischemia/reperfusion (t I/R). The involvement of the Notch pathway, and their modulation by the antioxidant genistein is also studied. Three groups of male Sprague-Dawley rats were used: sham rats, t I/R rats, and genistein-treated rats (10 mg/kg). The t I/R rat model un...

Melatonin was orally given to rats at the dosage of 0.75 mg/rat/day for 7 days and challenged on the day 7 with a single toxic dose of indomethacin (20 mg/kg, intramuscularly) to test either protection afforded by melatonin against indomethacin-induced oxidative tissue damage or effects of repeated administration of this hormone on some testicular metabolic parameters. The results showed increa...

The silk dye effluent is one of the most potential harmful chemicals liberated in environment an unexpected manner. Silk waste widely used as a potent dyeing yarn and fabrics many countries has been shown to produce some adverse health effects. This work focuses primarily on effects Moringa oleifera leaf extract testis induced surface ultrastructure Swiss albino mice Mus musculus. taken account...

Cadmium is a heavy metal that can accumulate to toxic levels in the environment leading to detrimental effects in animals and humans including kidney, liver and lung injuries. Using a transcriptomics approach, genes and cellular pathways affected by a low dose of cadmium were investigated. Adult largemouth bass were intraperitoneally injected with 20μg/kg of cadmium chloride (mean exposure leve...

Background: Male infertility is responsible for approximately 50% of infertility in the world. Reactive oxygen species (ROS) is one of the causative agents of infertility in males which effects on sperm quality and function. In this study, the effects of oxidative stress induced by tertiary-butyl hydroperoxide (TBHP) were investigated on sperm quality, testis tissue and miRNAs expression. Mater...