Testicular biopsy was considered the cornerstone of male infertility diagnosis for many years in men with unexplained infertility and azoospermia. Recent guidelines for male infertility have limited the indications for a diagnostic testicular biopsy to the confirmation of obstructive azoospermia in men with normal size testes and normal reproductive hormones. Nowadays, testicular biopsies are m...

INTRODUCTION Testicular germ cell tumors are the most common malignancies in men. Testicular torsion is also a scrotal phenomenon seen in adolescence and adulthood. The co-occurrence of these two scrotal disorders is extremely rare. CASE PRESENTATION A 28-year-old East Asian man presented at our hospital with painless bilateral scrotal swelling. Both scrotal ultrasonography and computed tomog...

BACKGROUND The xenografting of pre-pubertal human testicular tissue to an immunodeficient mouse is a theoretical strategy for restoring fertility in childhood cancer patients, while circumventing the risk of malignant recurrence. This study aimed at comparing the grafting of pre-pubertal and adult murine testicular tissue, as well as that of human adult testicular tissue, to two immunodeficient...

Objective To investigate effects of cryopreservation on changes of the ultrastructure of human testicular sperm and evaluate the efficacy of cryopreserving testicular tissue as a source of sperm for assisted reproduction. Methods Testicular biopsy tissues were obtained from infertile patients (n=12) with obstructive azoospermia and cryopreserved. Testicular sperm motility was observed after in ...

testicular cancer is one of the commonest cancers in men of working age, and is increasing in incidence in europe and north america. one suggested mechanism of causation is that there is impaired differentiation of germ cells in the pre- or perinatal period, followed by malignant transformation in later life, possibly by a hormonal mechanism. endocrine disrupting chemicals (edcs) have been a ma...

Testicular torsion is a well known urological emergency most common in the paediatric population. However, testicular can be complete, partial or intermittent. Intermittent rare adults and difficult to diagnose. We present case on intermittent 35 year old man that was initially misdiagnosed but later diagnosed by Spectral Doppler ultrasound.

Polycyclic aromatic hydrocarbons (PAHs), like benzo[a]pyrene (BaP), are ubiquitous environmental pollutants formed by the incomplete combustion of organic materials. The tripeptide glutathione (GSH) is a major antioxidant and is important in detoxification of PAH metabolites. Mice null for the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in GSH synthesis, have ...

Testicular scintigraphy has been well validated in the evaluation of patients with suspected testicular torsion and provides an accurate evaluation of testicular perfusion at the lime of imaging. However, the presence of normal or increased perfusion to the testis does not definitively exclude the necessity for surgical intervention. A case of intermittent testicular torsion, with a revie...

Testicular cell proliferation and differentiation is critical for development of normal testicular function and male reproductive maturity. The objective of the current study was to evaluate histoarchitecture and expression of genes marking specific cells and important functions as well as testosterone production of the developing goat testes. Testes were harvested from Alpine bucks at 0, 2, 4,...

BACKGROUND The mini-pubertal period of almost six hours in neonatal male rats is thought to be an important stage in sexual development. OBJECTIVES The aim of this study was to investigate the effect of hormone inhibition during mini-puberty on testicular function in male rats. MATERIALS AND METHODS We measured serum testosterone (T), luteinizing hormone (LH) and follicle-stimulating hormon...