نتایج جستجو برای: testicular germ cell
تعداد نتایج: 1710557 فیلتر نتایج به سال:
Testicular cancer is an uncommon malignancy. Most of testicular cancers are of the germ cell tumor type and they can be classified into seminomas or nonseminomas. The most common presentation of testicular cancer is a painless testicular nodule. Alpha-fetoprotein can be elevated in nonseminomas, while beta-human chorionic gonadotropin is usually elevated in both seminomas and nonseminomas. Radi...
We show with transgenic mice that targeted overexpression of glial cell line-derived neurotrophic factor (GDNF) in undifferentiated spermatogonia promotes malignant testicular tumors, which express germ-cell markers. The tumors are invasive and contain aneuploid cells, but no distant metastases have been found. By several histological, molecular, and histochemical characteristics, the GDNF-indu...
OBJECTIVES Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population. MATERIALS AND ME...
Testicular tumours are uncommon but constitute an important group of malignancies in young men. Worldwide, it is estimated that there were more than 48 500 new cases and 8900 deaths from the disease in 2002.1 The vast majority are primary germ cell tumours (GCTs) and the incidence has doubled in the past 30 years (with most of the increase in seminomas).2 While most patients present with early-...
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