manipulating spindle by laser, we showed that the spindle asymmetry is essential for asymmetric nuclear localization of b-catenin. Because a kinesin inhibitor disrupted asymmetry of b-catenin localization, we propose that kinesin dependent transport of b-catenin along astral microtubules causes the enhancement of nuclear b-catenin export. This process occurs more efficiently in the anterior sid...

Dopa Decarboxylase (Ddc) is an enzyme that plays a fundamental role in the biosynthesis of catecholamine neurotransmitters and serotonin. A short form transcriptional variant of Ddc called Ddc_exon1a which originates from an alternative promoter at exon 1a, is highly expressed in the trabecular cardiomyocytes during development of pre-natal heart and is progressively silenced during post natal ...

model in which cytoskeletal dynamics can be analysed with the wide range of genetic strategies and tools available for Drosophila. Morphological features and cytoskeletal dynamics closely resemble those of vertebrate GCs, suggesting this model to be of high translatable value. We will report subcellular roles of the actin-microtubule linker molecule Short stop (Shot; homologue of ACF7 and BPAG1...

ABSTRACTPrevious studies have shown the role of opioid receptors located in the nucleus cuneiformis (CnF) in acute pain, but not in chronic pain models. In the present study, we have determined that possible effects of these receptors at the CnF on both early and late phases of formalin test following local and systemic morphine administration. Each rat was given a subcutaneous 50-μl injection ...

BACKGROUND Trichoepithelioma is a rare benign skin lesion that originates from hair follicles. Trichoepitheliomas are mostly seen in the scalp, nose, forehead, and upper lip. METHODS We present a large family of Iranian origin with 15 individuals affected with multiple familial trichoepithelioma in four generations, and treated with three different methods. RESULTS Trichoepithelioma is his...