Transposable elements (TEs) are families of small DNA sequences found in the genomes of virtually all organisms. The sequences typically encode essential components for the replicative transposition sequences of that TE family. Thus, TEs are simply genomic parasites that inflict detrimental mutations on the fitness of their hosts. Several models have been proposed for the containment of TE copy...

A key challenge in multi-electrode transcranial electrical stimulation (TES) or transcranial direct current stimulation (tDCS) is to find a current injection pattern that delivers the necessary current density at a target and minimizes it in the rest of the head, which is mathematically modeled as an optimization problem. Such an optimization with the Least Squares (LS) or Linearly Constrained ...

The mobilized thermal energy storage system (M-TES) has been demonstrated as a promising technology to supply heat using waste heat in industries to distributed users, where heat discharging determines whether M-TES system can satisfy the required heating rate. The objective of this work is to investigate the solidification mechanism of phase change materials (PCM) for heat discharging in a dir...

Although several diploid and tetroploid Gossypium species genomes have been sequenced, the well annotated web-based transposable elements (TEs) database is lacking. To better understand the roles of TEs in structural, functional and evolutionary dynamics of the cotton genome, a comprehensive, specific, and user-friendly web-based database, Gossypium raimondii transposable elements database (GrT...

Transposable elements (TEs) are epigenetically silenced with extensive DNA methylation. The silent epigenetic marks should, however, be excluded from active genes. By genetic approaches, we study mechanisms to remove the heterochromatin marks from transcribed genes. Based on our observations on control of TE transcription, we propose a possible trigger for the TE-specific accumulation of DNA me...

Transposable elements (TEs) comprise nearly half of the human genome and play an essential role in the maintenance of genomic stability, chromosomal architecture, and transcriptional regulation. TEs are repetitive sequences consisting of RNA transposons, DNA transposons, and endogenous retroviruses that can invade the human genome with a substantial contribution in human evolution and genomic d...

Forecasting is of prime importance for accuracy in decision-making. For data sets containing high autocorrelations, failure to account for temporal dependence will result in poor forecasting. TES (Transform-Expand-Sample) is a class of stochastic processes to model empirical autocorrelated time series and is frequently used in Monte Carlo simulation. Its merit is to capture simultaneously both ...

Downlo ticular germ cell tumors (TGCT) originate from germ cells. The 129-Ter and M19 (129.MOLF-Chr19 mic) mouse strains have extremely high incidences of TGCTs. We found that the expression levels of coded splicing factor 1 (SF1) can modulate the incidence of TGCTs. We generated mice with inactivated null mice (Sf1−/−) died before birth. Mice with one intact allele of Sf1 (Sf1+/−) were viable ...

Transposable elements (transposons or TEs), which are capable of transferring segments of DNA (or of being transferred) from one site to another within a genome, are abundant in eukaryotic genomes. The highly repetitive, largely noncoding sequence that is prevalent in eukaryotic genomes consists largely of TEs. TEs make up nearly half of the human genome (Lander et al., 2001) and an estimated 5...

BACKGROUND Patients with nephrotic syndrome are at an increased risk of thromboembolic events (TEs). However, this association has not been thoroughly investigated in adult patients with idiopathic membranous nephropathy (IMN). METHODS A retrospective analysis of all 101 consecutive adult patients with MN diagnosed at our centre during 1995 to 2008 was performed. Pertinent data including thro...