Offspring born to mothers with hypertensive pregnancy have higher childhood blood pressure. We hypothesized this relates to prenatally programmed differences in the underlying vascular pathophysiology of the offspring and that these would be most apparent in those born preterm because of severe hypertension. We carried out a 20-year follow-up study of 71 subjects born preterm, 19 to a hypertens...

Introduction: The aim of this study was to investigate weight gain during pregnancy and birth weight in rural regions of Tabriz, a province in the northwest of Iran. Materials & Methods: A cross-sectional study was conducted using routinely collected data of pregnant mothers from rural health centers. Eight health centers were randomly selected in rural areas of Tabriz. Totally, 874 women aged...

Background: The timing of maternal weight change in pregnancy may be an important determinant of birth weight. The objective of this study was to measure weight gain patterns from early pregnancy until delivery, and to examine the relationship between prenatal weight gain and low birth weight. Methods: A total of 500 pregnant women within 15-20 days of conception, with confirmed pregnancies and...

BACKGROUND Post-term pregnancy is an important factor in perinatal mortality and morbidity. Generally, to reduce perinatal mortality in pregnancy, the delivery is done before adverse perinatal morbidity occurs. To prevent prolonged pregnancy, labor is induced with chemical drugs and complementary therapies. Due to the side effects and contraindications of chemical medicine, the use of herbs has...

BACKGROUND The objective of this study was to examine the association of maternal and paternal height with pregnancy length, and with the risk of pre- and post-term birth. In addition we aimed to study whether cardiovascular risk factors could explain possible associations. METHODS Parents who participated in the Nord-Trøndelag Health Study (HUNT 2; 1995-1997) were linked to offspring data fr...

background: ca-125 is a glycoprotein and its origin is uncertain during pregnancy. it arises during the first trimester and return to a non-pregnancy range in late pregnancy. objective: the aim of this study was to compare ca-125 level in threatened abortion and normal pregnancy less than 20 weeks of pregnancy. materials and methods: this was a prospective case study carried out on 50 healthy p...

Cigarette smoking during pregnancy is associated with numerous obstetrical, fetal, and developmental complications, as well as an increased risk of adverse health consequences in the adult offspring. Nicotine replacement therapy (NRT) has been developed as a pharmacotherapy for smoking cessation and is considered to be a safer alternative for women to smoking during pregnancy. The safety of NRT...

There is a well-documented reduction in endometrial cancer risk with combined oral contraceptive (COC) use. COC use before the first full-term pregnancy may affect breast cancer risk for decades, but this relationship has not been investigated in endometrial cancer. We investigated the risk for endometrial cancer with COC use before the first full-term pregnancy. Cases (n = 524) from a populati...

In this paper, we examine factors associated with poor pregnancy outcomes among teenagers in South Nyanza region of Kenya. The analysis is based on a recent WHO funded study on Adolescent safe motherhood in the region, which involved a survey of 1247 adolescents aged 12-19 and in-depth interviews with 39 of the adolescents who had experienced very early pregnancies or a pregnancy wastage. The i...

The fever response is blunted at near term. As the enzyme cyclooxygenase-2 (COX-2) plays a critical role in fever development, we measured its expression in rat hypothalamus during pregnancy and lactation. Western blot analysis revealed a 72-kDa COX-2-immunoreactive band in non-immune-challenged, pregnant rats at day 15 of pregnancy. In contrast, it was almost undetectable at near term and at l...