We aimed to evaluate the potential of growing rats as a model of osteoporosis induced by short term hypercholesterolemia. Twelve growing female Sprague-Dawley rats were randomly allocated into two groups. Control rats received standard diet while rats in group 2 were fed with diet contained 20% sunflower oil, 2% cholesterol and 0.5% cholic acid for 2 weeks and then a diet contained 10% sunflowe...

Alzheimer's disease (AD) accounts for a significant proportion of long-term care costs. The recent discovery that the e4 allele of the ApoE gene indicates a predisposition to earlier onset of AD raises questions about the potential for adverse selection in long-term care insurance, about long-term care costs in general, and about the potential effects on costs of gene therapy, or better targett...

Short-term water demand modeling plays a key role in urban water resources planning and management. The importance of demand prediction is even greater in countries like Iran with frequent periods of drought. Short-term water demand estimation is useful for planning and management of water and wastewater facilities such as pump scheduling, control of reservoirs and tanks volume, pressure manage...

abstract stochastic model for synthetic data generation is not available for daily flows of intermittent streams. such a model is required in the planning and operation of structures on an intermittent stream for purposes where short time flow fluctuations are important. in this study a model is developed for such a case. the model consists of four steps: determination of the days on which flow...

Streamflow forecasting has an important role in water resource management (e.g. flood control, drought management, reservoir design, etc.). In this paper, the application of Adaptive Neuro Fuzzy Inference System (ANFIS) is used for long-term streamflow forecasting (monthly, seasonal) and moreover, cross-validation method (K-fold) is investigated to evaluate test-training data in the model.Then,...

in this paper, a three-dimensional finite element model has been developed to simulate the laser-tig hybrid welding (hlaw) of stainless steel 1.4418 with thickness of 4 mm. transient temperature profile and dimensions of the fusion zone and heat affected zone (haz) during welding process are calculatedusing finite element method (fem) and were solved in the abaqus/standard software.the heat sou...

As suggested by Palop and Mucke (2010) pathologically elevated β-amyloid (Aβ) impairs long term potentiation (LTP) and enhances long term depression (LTD) possible underlying mechanisms in Alzheimer's Disease (AD). In the present paper we adopt and further elaborate a phenomenological computational model of bidirectional plasticity based on the calcium control hypothesis of Shouval et al. (2002...

Many physiological events require an accurate timing signal, usually generated by neural networks called central pattern generators (CPGs). On the other hand, properties of neurons and neural networks (e.g. time constants of neurons and weights of network connections) alter with time, resulting in gradual changes in timing of such networks. Recently, a synaptic weight adjustment mechanism has b...

conclusions by controlling the modifiable risk factors and modality of treatment in our study, physicians can reach more effective treatment. results at the end of the study, long-term graft failure was seen in 27 (10.2%) cases. one-year and 2-year graft survival after diagnosis of cancer were 93.6% and 91.7%, respectively. the univariate analysis showed that the incidence of chronic graft loss...