A brief review of the literature precedes the presentation of a radiation behavioral teratology study. The various types of radiation and the units of measure used in radiation biology are discussed. The concept of the radiation-induced teratogenic "triad" of growth retardation, malformation, and death is presented. A discussion of stage- and dose-dependent sensitivity to prenatal irradiation i...

Publications 1. Merucci P., Taggi F., Marolla A., Abbolito M.R., Vitelli G., Marolla P., Meliffi L., Chiarotti F., Menniti Ippolito F., Ameglio F. (1984). “Disciminant Analysis of Hodgkin's disease and non-Hodgkin's Lymphomas by Age and Serum Proteins”. European Journal of Cancer and Clinical Oncology, Vol. 20(10), pp. 1243-1247. 2. Chiarotti F., Alleva E., Bignami G. (1987). “Problems of test ...

The aryl hydrocarbon receptor (encoded by the Ahr locus) is a ligand-activated transcription factor that mediates the toxicology and teratology of 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). In an effort to understand the role of the maternal compartment in dioxin teratology, we designed a breeding strategy that allowed us to compare the teratogenic response in embryos from Ahr(-/-) (null) an...

Correspondence address: Assoc Prof. Eduard Ujházy, PhD. Department of Reproductive Toxicology, Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovakia, e-mail: [email protected] Studies of individual development and its possible deterioration have been the concern since the 19th century, when Etienne Geoffroy de Saint-Hilaire (1772...

AravaTM (leflunomide) is a pyrimidine synthesis inhibitor used in the treatment of active rheumatoid arthritis (RA). The chemical name for leflunomide is N-(49-trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide. Because the drug has been successful in the treatment of rheumatoid arthritis, it is being widely prescribed. In spite of the clear warning that the drug should not be prescribed fo...

The new fields of behavioral toxicology and behavioral teratology investigate the outcome of specific toxic exposures in humans and animals on learning, memory, and behavioral characteristics. Three important classes of behavioral neurotoxicants are metals, solvents, and pesticides. The clearest data on the deleterious effects of prenatal exposure to toxicants comes from the study of two metals...

PURPOSE Medication use during pregnancy is common and increasing. Women are also increasingly getting healthcare information from sources other than their physicians. METHODS This report summarizes an environmental scan that identified 25 active Internet sites that list medications reported to be safe for use in pregnancy and highlights the inadequate evidence base and inconsistent guidance p...

Due to the scope of the discipline, an annual survey of teratology must encompass a broad spectrum of findings from the bio-medical sciences. The first volume in this series does range topically in including reviews on aspects of cytogenetic, pharmacological, radiobiological, and immunological problems. If a field such as teratology is to be reviewed, one cannot expect a high degree of correspo...

With increasing incrimination of viruses, plants, and drugs as causes of ovine congenital defects, concerted efforts are required to identify environmental teratogens. Expanding knowledge of congenital defects requires studying as many defective lambs as possible; recording and documenting; detailed diagnostic examinations; genetic analyses and chromosomal examinations, whenever possible; and f...