We have tested 35 teratogenic and 20 nonteratogenic chemicals or drugs in a short-term, in vitro assay that identifies teratogens by their ability to inhibit growth of an established line of human embryonic palatal mesenchymal cells. Only those chemicals that exhibited a dose-dependent inhibition of growth at concentrations less than 1 mM were classified as inhibitory. An Aroclor-induced rat li...

In syndromic immunodeficiencies, clinical features not directly associated with the immune defect are prominent. Patients may present with either infectious complications or extra-immune medical issues. In addition to the immunologic abnormality, a wide range of organ systems may be affected. Patients may present with disturbances in skeletal, neurologic, dermatologic, or gastrointestinal funct...

Unintended pregnancy among adolescents and young adults (AYAs) with rheumatic disease has higher risk to mother fetus through the itself, contraindications estrogen, high rates of teratogen use. However, because diseases are uncommon, few samples large enough describe risks. Our purpose was risk, use, estrogen AYAs disease. ages 14-26 assigned female at birth were recruited from outpatient pedi...

Abstract Previous studies have suggested that arsenic crosses the placenta and affects fetus development. The study under consideration aims to show comparative ameliorative effect of Moringa oleifera leaf flower extracts against sodium arsenate induced toxicity mice. Pregnant mice (N=44) were kept in lab divided into eleven group from (A K) orally administered doses 6 mg/kg, 12 mg/kg for arsen...

Background In the UK, simulation in midwifery education mostly relates to developing clinical skills such as managing obstetric emergencies. However, there is minimal use of neonate simulators educating student midwives on impact teratogens fetal development. There also limited research using neonatal a creative pedagogical tool undergraduate education. Objectives The two main objectives this s...

Background: Prescribing pattern in pregnancy population provide insights during drug profile and also minimizes the inherent risks due to unethical prescribing. The study aimed evaluate prescribing of drugs among pregnant women. irrational use is a concern for present-day medical practice. Objectives: To assess FDA category using determine percentages women prone possible teratogens, namely C, ...

This review article discusses the epidemiology, risk factors, prenatal screening, diagnosis, prevention potentials, and epidemiologic impact of neural tube defects (NTDs). The average incidence of NTDs is 1/1000 births, with a marked geographic variation. In the developed countries, the incidence of NTDs has fallen over recent decades. However, it still remains high in the less-developed countr...

Concern about the potential health hazards resulting from environmental pollution by the chlorinated dibenzo-p-dioxins and dibenzofurans arises from our recognition of the extraordinary potency of these compounds as toxins and teratogens and their inadvertant dispersion in the environment as contaminants of chlorinated phenolic products. Questions concerning the extent of environment contaminat...