Biophysical models of cardiac tension development provide a succinct representation of our understanding of force generation in the heart. The link between protein kinetics and interactions that gives rise to high cooperativity is not yet fully explained from experiments or previous biophysical models. We propose a biophysical ODE-based representation of cross-bridge (XB), tropomyosin and tropo...

BACKGROUND The use of neuromuscular blocking agents has previously been suggested to facilitate the dissection of the latissimus dorsi muscle during breast reconstructive surgery. The aim of this study was to quantify the influence of deep muscle relaxation on the force required to lift the latissimus dorsi muscle during flap preparation. METHODS After ethics approval and written informed con...

in this paper, the modified euler-bernoulli beam model is presented to examine the influence of surface elasticity and residual surface tension on the critical force of axial buckling of nanotubes in the presence of rotary inertia. an explicit solution is derived for the buckling loads of microscaled euler beams considering surface effects. the size-dependent buckling behavior of the nanotube d...

INTRODUCTION: Shoulder motion following rotator cuff repair is unavoidable and may results in changes in tension on the repair and changes in compression forces at the rotator cuff footprint. We set out to determine how tension within the rotator cuff tendons and motion of the shoulder affect the footprint compression forces of a rotator cuff repair using multiple repair techniques. Ultimately,...

We have measured the contact angle of microsized and nanosized alkane droplets partially wetting a model substrate using true noncontact atomic force microscopy. The large range of droplet sizes accessible using this technique allowed us to determine the contact line curvature dependence of the contact angle with unprecedented accuracy. Whereas previous studies aimed at explaining such a depend...

Effect of rotation on surface tension gradient driven flow, which is also known as Marangoni convective flow, during protein crystallization is modelled and studied computationally under microgravity conditions, where the surface tension gradient force is the main significant driving force. The axis of the externally imposed rotation, which is assumed to be either parallel or anti-parallel to t...

PETERSON, JOHN W., AND RICHARD J. PAUL. Effects of initial length and active shortening on vascular smooth muscle contractility. Am. J. Physiol. 227(5) : 1019-1024. 1974.-The active isometric tension-length relation has been studied in bovine mesenteric vein at 37°C under a variety of experimental conditions, including both passive and active changes in muscle length. The rest length Lo , defin...

The surface tension of compliant materials such as gels provides resistance to deformation in addition to and sometimes surpassing that owing to elasticity. This paper studies how surface tension changes the contact mechanics of a small hard sphere indenting a soft elastic substrate. Previous studies have examined the special case where the external load is zero, so contact is driven by adhesio...

The series connection of sarcomeres in a muscle raises the possibility of instabilities due to some sarcomeres being capable of greater isometric tension than others, due to non-uniform activation, cross-sectional area or sarcomere length. Such instabilities are heavily damped by the force-velocity curve and stabilized by passive tension. The variation of active tension with sarcomere length ma...