Telomerase, the enzyme that extends single-stranded telomeric DNA, consists of an RNA subunit (TER) including a short template sequence, a catalytic protein (TERT) and accessory proteins. We used site-specific UV cross-linking to map the binding sites for DNA primers in TER within active Tetrahymena telomerase holoenzyme complexes. The mapping was performed at single-nucleotide resolution by a ...

We present a promising first example towards controlling the properties of a self-assembling mineral film by means of the functionality and polarity of a substrate template. In the presented case, a zinc oxide film is deposited by chemical bath deposition on a nearly topography-free template structure composed of a pattern of two self-assembled monolayers with different chemical functionality. ...

Insulin-like growth factor-1 receptor (IGF-1R) is a growth factor receptor tyrosine kinase acting as a critical mediator of cell proliferation and survival. Novel 5-benzylidenethiazolidine-2,4-dione (5) and 5-(furan-2-ylmethylene)thiazolidine-2,4-dione (6) compounds were identified as potent and selective IGF-1R inhibitors via hierarchical virtual screening. Initial SAR and biological activity ...

Controlled induction of crystal nucleation is a highly desirable but elusive goal. Attempts to speed up crystallization, such as high super saturation or working near a liquid-liquid critical point, always led to irregular and uncontrollable crystal growth. Here, we show that under highly nonequilibrium conditions of spinodal decomposition, water crystals grow as thin wires in a template-less f...

We present a confocal microscopy study of 1.55 microm monodisperse silica hard spheres as they sediment and crystallize at the bottom wall of a container. If the particles sediment onto a feature less flat wall, the two bottom layers crystallize simultaneously and layerwise growth follows. If the wall is replaced by a hexagonal template, only layerwise growth occurs. Our results complement earl...

MODIFICATION OF DEPOSITION PROCESS PARAMETERS FOR UNIFORM INDIUM LAYER DEPOSITION Isaac Butt Old Dominion University, 2017 Director: Dr. Sylvain X. Marsillac The need for more efficient light to energy converting cells has long been a subject of research and development. With abundant availability of solar energy that the earth receives, the photovoltaic industry has sought materials that could...

We report the growth and properties of a-axis oriented GdBa,CusO,-a high T, thin films on (100) SrTi03 substrates by dc magnetron sputtering. It is found that GdBa,Cu,O,-s films on (100) SrTiO, exhibit a-oriented growth at higher substrate temperatures compared with YBaQtsO,-& films. By utilizing low-temperature-grown u-axis GdBazCu,O,_.s films (200 A in thickness) as a self-template, pure a-ax...