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PURPOSE To develop a simple method to extract the whole apolipoproteins (apo) including apoA-I in native high density lipoproteins (HDLs) and prepare discoidal Tanshinone IIA-loaded reconstituted HDL (TA-rHDLs) as a dual functional drug delivery system with plaque-site target and therapeutic promises in atherosclerotic lesions. METHODS A method based on isoelectric precipitation coupled with ...

Chronic allograft damage, defined by interstitial fibrosis and tubular atrophy (IF/TA), is a leading cause of allograft failure. Few effective therapeutic options are available to prevent the progression of IF/TA. We applied a meta-analysis approach on IF/TA molecular datasets in Gene Expression Omnibus to identify a robust 85-gene signature, which was used for computational drug repurposing an...

BACKGROUND AND PURPOSE TA is a branch of image processing that seeks to reduce image information by extracting texture descriptors from the image. TA of MR images of anatomic structures in mild AD and aMCI is not well-studied. Our objective was to attempt to find differences among patients with aMCI and mild AD and normal-aging subjects, by using TA applied to the MR images of the CC and the th...

Dr. Cynthia Finelli, Director of the Center for Research on Learning and Teaching in Engineering and research associate professor of engineering education at University of Michigan (U-M), earned B.S.E.E., M.S.E.E., and Ph.D. degrees from U-M in 1988, 1989, and 1993, respectively. Prior to joining U-M in 2003, she was the Richard L. Terrell Professor of Excellence in Teaching, founding director ...

Time Petri Nets (TPN) and Timed Automata (TA) are widely-used formalisms for the modeling and analysis of timed systems. A recently-developed approach for the analysis of TPNs concerns their translation to TAs, at which point efficient analysis tools for TAs can then be applied. One feature of much of this previous work has been the use of timed reachability analysis on the TPN in order to cons...

A T→A mutation in the promoter region of porcine myostatin (MSTN) gene has been identified in our previous work. This study analyzed the associations of the myostatin genotypes (TT, TA) caused by this mutation with birth weigh in Yorkshire pigs. Data from 211 unrelated individuals were collected three times from one breeding farm. Detections of the mutation were carried out by PCR-RFLPs approac...

Testate amoebae (TA) are a group of free-living protozoa, important in ecology and paleoecology. Testate amoebae taxonomy is mainly based on the morphological features of the shell, as examined by means of light microscopy or (environmental) scanning electron microscopy (SEM/ESEM). We explored the potential applications of confocal laser scanning microscopy (CLSM), two photon excitation microsc...