نتایج جستجو برای: tcr

تعداد نتایج: 12834  

Journal: :The Journal of Experimental Medicine 1997
Roger Sciammas P. Kodukula Q. Tang R.L. Hendricks J.A. Bluestone

Increased numbers of T cell receptor (TCR)-gamma/delta cells have been observed in animal models of influenza and sendai virus infections, as well as in patients infected with human immunodeficiency virus and herpes simplex virus type 1 (HSV-1). However, a direct role for TCR-gamma/delta cells in protective immunity for pathogenic viral infection has not been demonstrated. To define the role of...

Journal: :The Journal of Cell Biology 2000
Thomas Harder Marina Kuhn

Activation of T cell antigen receptor (TCR) induces tyrosine phosphorylations that mediate the assembly of signaling protein complexes. Moreover, cholesterol-sphingolipid raft membrane domains have been implicated to play a role in TCR signal transduction. Here, we studied the assembly of TCR with signal transduction proteins and raft markers in plasma membrane subdomains of Jurkat T leukemic c...

2014
Zhengyu Ma David N. LeBard Sharon M. Loverde Kim A. Sharp Michael L. Klein Dennis E. Discher Terri H. Finkel

Antigen recognition by T cells relies on the interaction between T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC). The pMHC-TCR interaction is two-dimensional (2D), in that both the ligand and receptor are membrane-anchored and their movement is limited to 2D diffusion. The 2D nature of the intera...

Journal: :Journal of Immune Based Therapies and Vaccines 2004
Cristina Musselli Svetlana Daverio-Zanetti Maurizio Zanetti

BACKGROUND: Immunity against the T cell receptor (TCR) is considered to play a central role in the regulation of experimental allergic encephalomyelitis (EAE), a model system of autoimmune disease characterized by a restricted usage of TCR genes. Methods of specific vaccination against the TCR of pathogenetic T cells have included attenuated T cells and synthetic peptides from the sequence of t...

Journal: :Immunity 2006
Rajat Varma Gabriele Campi Tadashi Yokosuka Takashi Saito Michael L Dustin

T cell receptor (TCR) signaling is initiated and sustained in microclusters; however, it's not known whether signaling also occurs in the TCR-rich central supramolecular activation cluster (cSMAC). We showed that the cSMAC formed by fusion of microclusters contained more CD45 than microclusters and is a site enriched in lysobisphosphatidic acid, a lipid involved in sorting ubiquitinated membran...

Journal: :The Journal of Experimental Medicine 1992
T Crompton H Pircher H R MacDonald

During thymus development CD4+ CD8+ precursor cells differentiate into mature CD4+ and CD8+ T cells expressing T cell receptors (TCR) that recognize foreign antigens in association with major histocompatibility complex (MHC) class II or I molecules, respectively. Studies with TCR transgenic mice have shown that the accumulation of mature CD4+ and CD8+ thymocytes is strongly skewed by the MHC re...

Journal: :The EMBO journal 1998
C Montixi C Langlet A M Bernard J Thimonier C Dubois M A Wurbel J P Chauvin M Pierres H T He

T-cell receptors (TCRs) upon binding to peptide-MHC ligands transduce signals in T lymphocytes. Tyrosine phosphorylations in the cytoplasmic domains of the CD3 (gammadeltaepsilon) and zeta subunits of the TCR complex by Src family kinases initiate the signaling cascades via docking and activation of ZAP-70 kinase and other signaling components. We examined the role of the low-density detergent-...

Journal: :Journal of immunology 2003
Divya J Mekala Terrence L Geiger

As CTL adhere to and lyze their targets, they extract cognate Ag-MHC and represent this on their own cell surface. Whether such self-presented cognate Ag stimulate the TCR of a CTL is uncertain. To analyze this, we examined TCR capping in response to self-presented Ag. We found that OVA peptide-specific OT-1 CTL that were pulsed with cognate peptide Ag did not cap their TCR, implying that the a...

Journal: :The Journal of Experimental Medicine 1995
D P Hughes A Hayday J E Craft M J Owen I N Crispe

Fas-mediated apoptosis is essential for activation-induced cell death of alpha/beta T cells, but it is not clear what role, if any, it plays in regulating other components of the immune system. To study the role of Fas in gamma/delta T cell development, Fas-deficient lpr mice were bred with T cell receptor alpha gene-ablated (TCR-alpha-/-) mice to generate mice deficient in one or both genes. T...

Journal: :International immunology 2004
Toshiki Tamura Haruyuki Ariga Tatsuo Kinashi Shuichiro Uehara Takeshi Kikuchi Makiyo Nakada Takeshi Tokunaga Wen Xu Ai Kariyone Takashi Saito Toshio Kitamura Gavin Maxwell Satoshi Takaki Kiyoshi Takatsu

CD4+ Th1 cells play a critical role in the induction of cell-mediated immune responses that are important for the eradication of intracellular pathogens. Peptide-25 is the major Th1 epitope for Ag85B of Mycobacterium tuberculosis and is immunogenic in I-Ab mice. To elucidate the role of the TCR and IFN-gamma/IL-12 signals in Th1 induction, we generated TCR transgenic mice (P25 TCR-Tg) expressin...

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