BACKGROUND The effects of dexmedetomidine on the propofol-sparing effect and intraoperative hemodynamics during remifentanil-based propofol-supplemented anesthesia have not been well investigated. METHODS Twenty patients undergoing breast surgery were randomly allocated to receive dexmedetomidine (group DEX) or placebo (group C). In the DEX group, dexmedetomidine was loaded (1 µg/kg) before a...

Objective To analyse the ecological and social factors involved in infestation of houses by Triatoma dimidiata a rural locality Veracruz, Mexico, where active transmission parasite is occurring. Methods A survey was applied to households obtain sociodemographic data. In parallel, T. insects were collected during one year through community participation. Using PCR, genotyped, their infection sta...

Background and Aim: The aim of the present study was to compare effect volatile induction maintenance anesthesia (VIMA) target controlled infusion (TCI) on cardiovascular stability in New York Heart Association (NYHA) grade II patients who underwent laparoscopic cholecystectomy. Patients methods: In study, 90 were randomized into two groups depending whether they received VIMA or TCI. rate, sys...

Target concentration intervention (TCI) is proposed as an alternative conceptual strategy to therapeutic drug monitoring (TDM). It is argued that the idea of a therapeutic range has limited the interpretation of measured drug concentrations and diminished the anticipated clinical benefit to patients by use of an oversimplified pharmacodynamic model. TCI on the other hand embraces pharmacokineti...

Climate extreme like drought significantly affect the quality of environment and threaten food availability in developing countries Ethiopia. In this study, satellite-based agricultural assessments were conducted 0main crop growing season (June to September) using Landsat 8 images five periods (2015 2019) Rift Valley Region To assess we used Normalized Difference Vegetation Index (NDVI), Land S...

Target controlled infusion (TCI) devices are increasingly used in clinical practice. These devices unquestionably aid optimization of drug dosage. However, it still remains to be determined if they sufficiently address differences in pharmacological make up of individual patients. The algorithms guiding TCI pumps are based on pharmacological data obtained from a relatively small number of healt...

Efforts to develop new hypnotic compounds continue, although several have recently failed in development. Propofol has been reformulated in various presentations with and without preservatives. Pharmacokinetic and pharmacodynamic differences exist between some of these preparations, and it is currently unclear whether any have substantial advantages over the original presentation. The use of ta...