Tuberculous meningitis (TBM) is a severe form of extrapulmonary tuberculosis. The aims of this study were to evaluate in-house molecular diagnostic protocols of DNA extraction directly from CSF samples and the targets amplified by qPCR as an accurate and fast diagnosis of TBM. One hundred CSF samples from 68 patients suspected of TBM were studied. Four DNA extraction techniques (phenol-chlorofo...

Relapsing polychondritis (RP) is a rare systemic autoimmune disease that affects cartilaginous structures. RP causes tracheobronchomalacia (TBM) by affecting the bronchial cartilage. TBM is a fatal condition characterized by excessive weakening of the walls of the trachea and bronchi. We herein report a case of a 73year-old man who experienced sudden respiratory failure due to TBM caused by RP....

Detailed 3-D neutronics calculations have been performed for the US DCLL TBM. The neutronics calculations were performed directly in the CAD model using the DAG-MCNP code that allows preserving the geometrical details. Detailed high-resolution, high-fidelity profiles of the nuclear parameters were generated using fine mesh tallies. These included tritium production, nuclear heating, and radiati...

The paper presents an approach to joint tracking and classification based on belief functions as understood in the transferable belief model (TBM). For the tracking phase, a Kalman filter in the TBM framework is derived. This filter is essentially the same as the classical Kalman filter with a diffuse prior, although it is derived in a more general context. For the classification phase, the TBM...

Tuberculous meningitis (TBM) is the most lethal form of tuberculosis, and new treatments that improve outcomes are required. We randomly assigned adults with TBM to treatment with standard antituberculosis treatment alone or in combination with ciprofloxacin (750 mg/12 h), levofloxacin (500 mg/12 h), or gatifloxacin (400 mg/24 h) for the first 60 days of therapy. Fluoroquinolone concentrations ...

A kidney tubular basement membrane (TBM) component that is bound by antibodies from individuals with anti-TBM antibody-associated tubulointerstitial nephritis (TIN) was purified and characterized (TIN antigen). TIN antigen was prepared from rabbit TBM by extraction with guanidine and purified by ion-exchange, gel filtration, and reversed-phase chromatography. Based upon yields of protein and an...

Introduction: Tubercular meningitis (TBM) remains a major global health problem and is the most dangerous form of extra-pulmonary tuberculosis. Therefore early, simple and inexpensive diagnostic test has always been a matter of concern especially in a developing country like India. Therefore we aimed in our study to find out the diagnostic significance of cerebrospinal fluid (CSF) and blood ade...

BACKGROUND Tracheobronchomalacia (TBM) is a pathologic condition in which softening of tracheal and bronchial cartilage causes the dynamic narrowing of transverse or sagittal diameters of tracheobronchial lumen; an excessive dynamic airway collapse (EDAC) may also be associated, with a substantial invagination of the posterior membrane of trachebronchial tree.The aim of this study was to assess...

Antigen 85 (Ag 85) complex, a component of M.tuberculosis bacilli (MTB) have been the focus of extensive research for diagnosis of tuberculosis for last several years. The aim of the present study to evaluate the status of primary tuberculosis infection in confirmed tuberculous meningitis (TBM) patients by estimating Ag 85 complex in Cerebrospinal Fluid (CSF) and serum specimen. A prospective s...

BACKGROUND A delay in the diagnosis and treatment of tuberculosis meningitis (TBM) may lead to increased mortality and morbidity. The aim of this study was to describe the clinical, radiological and laboratory findings of TBM on a cohort of 185 pediatric patients at a single centre over a 10 year period and to investigate relationship between the stage of the disease. METHODS The hospital rec...