Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide and leads serious longterm disability. To determine the effect of hydrogen-rich water on the angiogenesis in the lesion boundary brain tissue of TBI-challenged rats, 54 adult male Sprague-Dawley (SD) rats were used and randomly divided into three groups: sham-operated, TBI (Traumatic brain injury) and TBI+HW (Tra...

BACKGROUND AND PURPOSE Previous studies have identified an array of morbidities following traumatic brain injury (TBI), including certain neurological disorders. However, no direct evidence has been reported on the link between TBI and stroke. This population-based study was designed to estimate the risk of stroke during a period of 5 years following a TBI, compared with individuals who did not...

Abstract Background To compare the preventive effects of levetiracetam and valproate on late-onset post-traumatic seizures in patients with traumatic brain injury (TBI). Methods A total 95 TBI were recruited from 2017 to 2020. They randomized into three groups: (LEV) group ( n = 30) receiving LEV treatment (500 mg, bid, po); 32) sodium mg/d, once daily, control 33) no anti-seizure medication. g...

Abstract Introduction Mild traumatic brain injuries (TBI) induce persistent dysregulated sleep, reactive oxygen species (ROS), and inflammation. Nucleotide-binding domain leucine rich family pyrin containing 3 (NLRP3) inflammasomes are protein complexes that stimulate caspase-1 to activate the somnogenic pro-inflammatory cytokines IL-1β IL-18. ROS thioredoxin interacting (TXNIP) NLRP3 by inhibi...

AIM The study was designed to estimate the prevalence of traumatic brain injury (TBI) in a French prison population of female offenders, study the variables known to be associated with TBI, and compare our results with those obtained among male offenders as described in a previous paper. PARTICIPANTS All female offenders (adults and juveniles) consecutively admitted to Fleury-Mérogis prison o...

BACKGROUND Traumatic Brain Injury (TBI) may lead to significant impairments in personal, social and professional life. However, knowledge of the influence on long-term outcome after TBI is sparse. We therefore aimed to investigate the subjective effects of TBI on long-term outcome at a minimum of 10 years after trauma in one of the largest study populations in Germany. METHODS The current inv...

Traumatic brain injury (TBI) affects functioning of various organ systems in the absence of concomitant non-neurologic organ injury or systemic infection. The systemic manifestations of TBI can be mild or severe and can present in the acute phase or during the recovery phase. Non-neurologic organ dysfunction can manifest following mild TBI or severe TBI. The pathophysiology of systemic manifest...

The ability of simvastatin to mitigate the increases in risk factors for and the occurrence of cardiac disease after 10 Gy total body irradiation (TBI) was determined. This radiation dose is relevant to conditioning for stem cell transplantation and threats from radiological terrorism. Male rats received single dose TBI of 10 Gy. Age-matched, sham-irradiated rats served as controls. Lipid profi...

OBJECTIVE Traumatic brain injury (TBI) is the most common cause of death and disability in children and adolescents. Psychopathology is an established risk factor for, and a frequent consequence of, TBI. This paper reviews the literature relating psychopathology and TBI. METHOD Selective literature review. RESULTS The risk of sustaining a TBI is increased by pre-existing psychopathology (pa...

Traumatic brain injuries (TBIs) are injuries to the brain associated with the transfer of energy from some external source. There are an estimated 1.4 million TBIs each year, and about half are due to transportation crashes (NINDS, 2007). Driver distraction is defined as a process or condition that draws a driver's attention away from driving activities toward a competing activity (Sheridan, 20...