Increased oxidative stress is implicated in the pathogenesis of experimental diabetic neuropathy, but translational evidence in recent-onset diabetes is scarce. We aimed to determine whether markers of systemic oxidative stress are associated with diabetic sensorimotor polyneuropathy (DSPN) in recent-onset diabetes. In this cross-sectional study, we measured serum concentrations of extracellula...

Introdução: O tabagismo é considerado uma epidemia mundial e, segundo a Organização Mundial de Saúde (OMS), cerca cinco milhões pessoas morre cada ano em consequência das doenças relacionadas ao tabaco. tabaco, além vários efeitos nocivos, está relacionado com aumento células defesa. Objetivo: Avaliar viabilidade polimorfonucleares (PMNs) e o dano oxidativo no sangue indivíduos fumantes não atr...

OBJECTIVES This study investigated serum thiobarbituric acid-reactive substances (TBARS) and free thiol levels in different subtypes of acute ischemic stroke (AIS) and evaluated their association with clinical outcomes. METHODS This prospective study evaluated 100 AIS patients, including 75 with small-vessel and 25 with large-vessel diseases. Serum oxidative stress (TBARS) and antioxidant (th...

OBJECTIVE We determined the calcium activated adenosine triphosphatase (Ca-ATPase) activity and level of lipid peroxidation thiobarbituric acid-reactive substances (TBARS) of red blood cell ghosts in the antepartum and postpartum of normotensive and preeclamptic pregnant women. METHODS Samples of venous blood were obtained by venipuncture of nulliparous normotensive and preeclamptic pregnant ...

Malondialdehyde (MDA) is one of the most commonly reported biomarkers of lipid peroxidation in clinical studies. The reaction of thiobarbituric acid (TBA) with MDA to yield a pink chromogen attributable to an MDA-TBA₂ adduct is a common assay approach with products being quantified by ultraviolet-Vis assay as nonspecific TBA-reactive substances (TBARS) or chromatographically as MDA. The specifi...

In this work, the effect of copper and zinc on green alga Pseudokirchneriella subcapitata was evaluated through catalase activity, lipid peroxidation by TBARS essay, growth rate, and the chlorophyll-a concentration. Catalase activity increased significantly (P < 0.05) in comparison to the control at 0.1 mg L copper and 0.075 mg L zinc, whereas the damage to the cell membrane expressed as nmols/...

Extracts of Tinospora cordifolia (TCE) have been shown to possess anti-tumor properties, but the mechanism of the anti-tumor function of TCE is poorly understood. This investigation elucidates the possible mechanism underlying the cytotoxic effects of dichlormethane extracts of TCE, after selecting optimal duration and concentration for treatment. HeLa cells were exposed to various concentratio...

BACKGROUND/AIMS Nephropathic cystinosis (NC) is a severe systemic disease and cysteamine improves its prognosis. Lysosomal cystine accumulation is the hallmark of cystinosis and is regarded as the primary defect due to mutations in the CTNS gene. However, there is great evidence that cystine accumulation itself is not responsible for all abnormalities observed in NC. Studies have demonstrated a...

Vitex doniana (West African plum or black plum) is a plant with varying phytoconstituents and biological activities across different countries. In this study, essential oils extracted from the leaves fruits of cultivated in Ghana were investigated for their antimicrobial antioxidant activities. The actions determined using hydrogen peroxide (H2O2), phosphomolybdenum, thiobarbituric acid reactiv...

background: the aim of this study was to determine oxidative stress (os) parameters after testicular torsion/detorsion in adult rats. materials and methods: in this experimental study, male adult wistar rats were divided into four groups, each consisting of seven animals: group i-one hour right testicular torsion with subsequent orchiectomy, group ii-one hour right testicular torsion followed b...