Development of the taxoids has progressed rapidly in the 1990s. In vitro studies have demonstrated that docetaxel (Taxotere) has a longer residence time and higher accumulation within tumor cells than paclitaxel (Taxol), possibly accounting for its greater cytotoxicity. Animal studies have shown docetaxel to possess high antitumor activity. In clinical studies, docetaxel as a single agent has b...

BACKGROUND Di-2-ethylhexyl phthalate (DEHP) are added to poly(vinyl chloride)(PVC) infusion tubes as a plasticizer to ensure tube flexibility. In addition to previously reported disadvantages of DEHP, released DEHP molecules from PVC tubes can easily interact with surfactants in anticancer drug solutions (i.e., polysorbate 80 for Taxotere®-Inj) and reduce the solubility of docetaxel in aqueous ...

AIMS AND BACKGROUND Thyroid metastasis from nasopharyngeal carcinoma is a rare occurrence. We report a case of thyroid metastases from nasopharyngeal carcinoma with a review of the literature. METHODS In April 2007 a 59-year-old man was diagnosed with nasopharyngeal carcinoma; in October 2009 he underwent a thyroid biopsy that revealed G2 infiltrating spinocellular carcinoma with lymph node i...

Abraxis BioScience, Inc, presented data at the 29th Annual San Antonio Breast Cancer Symposium (SABCS) from an interim analysis of a randomized, head-to-head phase II trial of albumin-bound paclitaxel (Abraxane) vs docetaxel (Taxotere), in the first-line treatment of metastatic breast cancer. The interim analysis showed that first-line treatment with weekly albumin-bound paclitaxel (100 and 150...

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This document provides a glossary of terms used in the IETF when discussing internationalization. The purpose is to help frame discussions of internationalization in the various areas of the IETF and to help introduce the main concepts to IETF participants.

Nulling interferometry of exo-solar planets requires as a minimum two telescopes, of which one is phase shifted by 180 degrees, such that the on-axis stellar object is cancelled, while the light from the off-axis planet interferes constructively. Improvement of the nulling performance and the introduction of chopping leads to space interferometers of four or more telescopes and a separate space...