We previously reported that, in the brains of older patients with vascular dementia (VaD), there is a distinctive accumulation of detergent-extractable soluble amyloid-β, with a predominance of Aβ42 species. It is unclear, however, if tau proteins also accumulate in the brains of older VaD subjects. Using antibody-specific immunoassays, we assessed concentrations of total tau (t-tau) and phosph...

We perform an error analysis for numerical approximation methods of continuous time Markov chain models commonly found in the chemistry and biochemistry literature. The motivation for the analysis is to be able to compare the accuracy of different approximation methods and, specifically, Euler tau-leaping and midpoint tau-leaping. We perform our analysis under a scaling in which the size of the...

He i l10830 profiles acquired with Keck’s NIRSPEC for six young low-mass stars with high disk accretion rates (AS 353A, DG Tau, DL Tau, DR Tau, HL Tau, and SVS 13) provide new insight into accretion-driven winds. In four of the stars, the profiles have the signature of resonance scattering, and they possess a deep and broad blueshifted absorption that penetrates more than 50% into the 1 mm cont...

Down syndrome (DS) is the most prevalent chromosomal abnormality. Early-onset dementia with the pathology of Alzheimer's disease (AD) frequently develops in DS. Reliable blood biomarkers are needed to support the diagnosis for dementia in DS, since positron emission tomography or cerebrospinal fluid sampling is burdensome, particularly for patients with DS. Plasma t-tau is one of the establishe...

This paper is concerned with the numerical solution of Volterra integral equations third kind non-smooth solutions based on recursive approach spectral Tau method. To this end, a new set fractional version canonical basis polynomials (called FC-polynomials) introduced. The approximate polynomial Tau-solution) expressed in terms FC-polynomials. structure Tau-solution allows recovering standard d...

BACKGROUND Insulin resistance (IR) is linked with the occurrence of pathological features observed in Alzheimer's disease (AD), including neurofibrillary tangles and amyloid plaques. However, the extent to which IR is associated with AD pathology in the cognitively asymptomatic stages of preclinical AD remains unclear. OBJECTIVE To determine the extent to which IR is linked with amyloid and t...

The elevated level of cerebrospinal fluid (CSF) Tau and phosphorylated Tau181 (p-Tau181) proteins are well established hallmarks of Alzheimer's disease (AD). Elevated level of p-Tau181 can differentiate AD from other neurodegenerative disease. However, the expression level of these proteins in serum of AD patient is not well set up. This study sought to evaluate the level of Tau and p-Tau181 in...

Low levels of amyloid-beta42 (Abeta42) and high total-tau (t-tau) or phosphorylated-tau (p181-tau) levels in cerebrospinal fluid (CSF) were shown to be characteristic for Alzheimer's disease (AD) patients and for mildly cognitively impaired (MCI) or non-demented individuals who will progress to AD. The goal of this study was to evaluate the benefit of CSF biomarker testing in a setting with no ...

Three binary systems in the Hyades open cluster (51 Tau, V818 Tau, and θ2 Tau), with known metallicity and good Johnson photometric data are used to test the validity of three independent sets of stellar evolutionary tracks. A statistical method is described and applied to the colour-magnitude diagram of the six selected components, giving rise to χ2-contours in the metallicity–age plane. The e...

Background While cutoffs for abnormal levels of the cerebrospinal fluid (CSF) biomarkers amyloid β 1-42 (Aβ 1-42), total tau (t-tau), phosphorylated (p-tau), and ratios t-tau/Aβ p-tau/Aβ 1-42, have been established in Alzheimer’s disease (AD), biologically relevant not studied extensively Parkinson’s (PD). We aim to assess suitability diagnostic accuracy AD-derived CSF biomarker PD population. ...