نتایج جستجو برای: targeting
تعداد نتایج: 148077 فیلتر نتایج به سال:
We study two types of targeting in this paper, exogenous targeting and endogenous targeting. By exogenous targeting we mean targeting by product preferences: advertising levels and prices geared to specific consumer preferences. Exogenous targeting presumes observability of consumer preferences (or of factors correlated with them). This is the sort of targeting that is much in the news in conte...
Abstract Purpose: our goal is to reduce the release rate of methotrexate (MTX) and increase cell death efficiency. Methods: Carboxylated multi-walled carbon nanotubes (MWCNT-COOH) were functionalized with MTX as a cytotoxic agent, FA as a targeting moiety and polyethylene amine (PEI) as a hydrophilic agent. Ultimately, MWCNT-MTX and MWCNT-MTX-PEI-FA were synthesized. Methotrexate re...
Abstract Purpose: our goal is to reduce the release rate of methotrexate (MTX) and increase cell death efficiency. Methods: Carboxylated multi-walled carbon nanotubes (MWCNT-COOH) were functionalized with MTX as a cytotoxic agent, FA as a targeting moiety and polyethylene amine (PEI) as a hydrophilic agent. Ultimately, MWCNT-MTX and MWCNT-MTX-PEI-FA were synthesized. Methotrexate re...
New technologies are changing the way in which gene targeting experiments are being designed. It is now becoming possible to analyze gene function in defined tissues at specific times during the life of a mouse.
We have compared the efficiency of transformation by linear DNA fragments in yeast strains carrying different numbers of homologous targets for recombination. In strains carrying dispersed copies of a target and in strains carrying tandem arrays, the frequency of transformation is proportional to the number of targets. This result is in contrast to previous studies of transformation in mammalia...
the use of animal models in modeling of human genetic disease has many advantages. in some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. they ar...
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