Downloa cer chemotherapy exploits limitations in repairing DNA damage in order to kill proliferating nant cells. Recent evidence suggests that cancers within and across tissue types have specific defects A repair pathways, and that these defects may predispose for sensitivity and resistance to various s of cytotoxic agents. Poly (ADP-ribose) polymerase (PARP) and BRCA proteins are central to th...

Human immunodeficiency virus type 1 (HIV-1) Tat and human Cyclin T1 form a complex and together recognize the viral TAR RNA element with specificity. Using HIV-1/equine infectious anaemia virus TAR chimeras, we show that in addition to the well-characterized interaction with the bulge, Tat recognizes the distal stem and the loop of TAR. These data support previously proposed, but unproven, mole...

Download wth factors and many oncogenes activate the lipid kinase phosphoinositide 3-kinase (PI3K), ing a signaling cascade that includes the protein kinases AKT and target of rapamycin (TOR). The AKT/TOR signaling pathway is a significant contributor to disease in various human cancers, includmatologic malignancies. Here we discuss different strategies to inhibit TOR for the treatment of ia, l...

We have identified coal tar pitch, a very cheap organic material made from coal during the iron-making process, as a source from which could be obtained emissive molecules for organic light-emitting diodes. Coal tar pitch was separated by simple dissolution in organic solvent, and subsequent separation by preparative thin-layer chromatography was used to obtain emissive organic molecules. The r...

Regulation of HIV gene expression is crucially dependent on binding of the trans-activator protein, Tat, to the trans-activation response RNA element, TAR, found at the 5' end of all HIV-1 transcripts. Tat-TAR interaction is mediated by a short arginine-rich domain of the protein. Disruption of this interaction could, in theory, create a state of complete viral latency. A new class of small-mol...

Total ankle joint replacement (TAR) has been offered as an alternative to ankle joint arthrodesis since the 1970s. TAR offers the benefit of perseveration of joint motion, with potential decreased occurrence of adjacent joint degeneration, and a more expedient path to weight bearing. Since their introduction, TAR devices have undergone a variety of modifications, specifically in regards to the ...

The yields of char, tar, and non-condensible gases from the pyrolysis of Pinus radiata D. Don bark were measured. Pyrolysis of bark, on a small preparative scale using an airacetylene flame, gave 48% char with ash content 3.5% (mainly aluminium, calcium, potassium, and silica), and recovered tar in 7% yield (on oven-dried bark equivalent). The major components of the pyrolysis tar were catechol...

Purpose: To evaluate patient satisfaction, the retentive characteristics, and masticatory efficiency in maxillary single denture wearers with 3 different bases. Material Methods: 40 patients; 10 dentate (control group (GC)) 30 completely edentulous ridges patients (43-56 years) were selected for this study. The divided into groups randomly; each received dentures; Group I (GI) conventional heat...

Given the importance of auxin, it has been surprisingly difficult to elucidate its biosynthetic pathways in plants. Several Trpdependent routes have been proposed, in which CYTOCHROME P450 79B2/B3 (CYP79B2/B3), YUCCA (YUC), and TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS1/TRYPTOPHAN AMINOTRANSFERASE RELATED (TAA1/TAR) genes have been thought to act in separate pathways (reviewed in Zhao, 2010). ...