Cells respond rapidly to changes in their internal and external environments, often by using post-translational protein modifications to transmit signals from the cell surface or internal sites to the nucleus. These signaling pathways allow cells to respond to growth signals, tolerate stresses or trigger programmed cell death. In general, signaling pathway activation is transient, with feedback...

IL-33 is constitutively expressed in the skin. Psoriasis a common skin inflammatory disease. The roles of psoriasis have not been well-elucidated. We identified that keratinocytes (KCs) are predominant cells expressing and its receptor, suppression tumorigenicity 2, KCs actively released on stimuli induced psoriasis-related cytokine, chemokine, molecules genes transcription an autocrine manner....

Identifying intracellular molecular interactions is the first step toward understanding complex dynamics and mechanisms of the cell. We have created a comprehensive map of molecular interactions in a macrophage based on published literature. The map was created to analyze the experimental data sets produced by the Alliance for Cellular Signaling (AfCS). Therefore, we have extensively focused on...

Boswellia resin is a major anti-inflammatory agent in herbal medical tradition, as well as a common food supplement. Its anti-inflammatory activity has been attributed to boswellic acid and its derivatives. Here, we re-examined the antiinflammatory effect of the resin, using inhibitor of nuclear factorB (I B ) degradation in tumor necrosis factor (TNF) -stimulated HeLa cells for a bioassay-guid...