OBJECTIVE Renal dysfunction is a key risk factor for all-cause mortality in patients with type 2 diabetes (T2D). Circulating tumor necrosis factor receptor 1 (TNFR1) was recently suggested as a strong biomarker for end-stage renal failure in T2D. However, its relevance regarding all-cause death has yet to be conclusively established. We aimed to assess the prognostic value of serum TNFR1 concen...

Type 2 diabetes mellitus (T2D) is a slowly progressive disease that can be postponed or even avoided through lifestyle changes. Recent data demonstrate highly significant correlations between DNA methylation and the most important risk factors of T2D, including age and body mass index, in blood and human tissues relevant to insulin resistance and T2D. Also, T2D patients and individuals with inc...

OBJECTIVE To obtain estimates of the effects of overweight and obesity on the incidence of type 2 diabetes (T2D) and adult mortality. MATERIALS AND METHODS We use three waves (2000, 2002, 2012) of the Mexican Health and Aging Survey (MHAS).We employ parametric hazard models to estimate mortality and conventional logistic models to estimate incidence of T2D. RESULTS Obesity and overweight ha...

With rapidly increasing prevalence, diabetes has become one of the major causes of mortality worldwide. According to the latest studies, genetic information makes substantial contributions towards the prediction of diabetes risk and individualized antidiabetic treatment. To date, approximately 70 susceptibility genes have been identified as being associated with type 2 diabetes (T2D) at a genom...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for disease 2019 (COVID-19), uses angiotensin-converting enzyme to invade human cells. However, recent evidence suggested that dipeptidyl peptidase 4 (DPP-4) may be used as a coreceptor when SARS-CoV-2 enters target cells (1). Interestingly, upregulation of DPP-4 is associated with older age, or cardiovascul...

Analysis of territorial diabetes mellitus registers of 2 Western and 3 Eastern Ukraine regions with diverse historical backgrounds was performed. Two western regions (Kherson and Crimea) were severely affected by Famine of 1932-33, Chernihiv region was less severely affected area, and Western-Ukraine regions (Volyn and Rivne) were not affected. Prevalence rates of diagnosed type 2 diabetes mell...

◾ Type 2 diabetes (T2D) is a leading cause of cardiovascular disorders, blindness, renal failure, and amputations, and is associated with an increased risk of numerous other medical problems1 ◾ Weight control is a cornerstone of T2D management, and is included in the joint treatment guidelines from the American Diabetes Association and European Association for the Study of Diabetes1 ◾ Previous ...

Intrauterine growth restriction (IUGR) leads to development of type 2 diabetes (T2D) in adulthood. The mechanisms underlying this phenomenon have not been fully elucidated. Inflammation is associated with T2D; however, it is unknown whether inflammation is causal or secondary to the altered metabolic state. Here we show that the mechanism by which IUGR leads to the development of T2D in adultho...

AIMS This study sought to compare type 2 diabetes (T2D) risk indicators in Iraqi immigrants with those in ethnic Swedes living in southern Sweden. METHODS Population-based, cross-sectional cohort study of men and women, aged 30-75 years, born in Iraq or Sweden conducted in 2010-2012 in Malmö, Sweden. A 75g oral glucose tolerance test was performed and sociodemographic and lifestyle data were ...