The human brain thalami play essential roles in integrating cognitive, sensory, and motor functions. In multiple sclerosis (MS), quantitative magnetic resonance imaging (qMRI) measurements of the thalami provide important biomarkers of disease progression, but late development and aging confound the interpretation of data collected from patients over a wide age range. Thalamic tissue volume los...

In this study, diffusion tensor imaging (DTI) and T(2)* multiechorelaxometry were combined in 30 healthy subjects at 3T, with the aim of characterizing the spatial distribution of relaxation rates in white matter (WM). Region of interest (ROI) analysis was performed in 23 different fiber tracts automatically defined in standard space. Spearman rank analysis was performed on regional values of T...

Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI rela...

In unselected patients with intractable temporal lobe epilepsy (TLE), approximately 15% do not have detectable hippocampal atrophy on MRI. The purpose of this study was to evaluate whether T2 relaxometry can identify hippocampal pathology and lateralize the epileptic focus in patients with intractable TLE, who do not demonstrate hippocampal atrophy on volumetric MRI (MRIV). We selected 14 patie...

Iron can contribute to the pathogenesis and progression of multiple sclerosis (MS) due to its accumulation in the human brain. We focus on the thalamus as an information transmitter between various subcortical and cortical areas. Thalamic iron seems to follow different rules than iron in other deep gray matter structures and its relation to the clinical outcomes of MS is still indistinct. In ou...

Background Myocarditis is a common inflammation of the myocardium with variable symptoms, which is in daily clinical routine quite difficult to diagnose. Cardiac magnetic resonance imaging assumes an increasingly important role in the diagnosis of myocarditis by their exact functional analysis and the possibility of representation of tissue changes. The aim of this clinical trial consists in th...

Background Intramyocardial hemorrhage (IMH) secondary to myocardial infarction (MI) is associated with adverse prognosis [1]. The byproducts of blood breakdown lead to decreases in T2 and T2*, and have been shown to be related to microvascular obstruction (MVO) as detected by early contrast enhanced (EGE) imaging [2]. However, EGE is heavily influenced by contrast agent kinetics and measures th...

Rationales and objectives: In recent years, numerous studies have been published on the use of iron oxide nanoparticles for MRI assessment of macrophage infiltration in neuroinflammatory diseases [1]. Quantitative estimate of iron-labelled cells is highly desirable in such studies, as it could allow to monitor the effects of anti-inflammatory drugs. In-vitro studies performed at 4.7T [2] have s...

Background Reperfusion injury in acute myocardial infarction (MI) results in edema, necrosis, microvascular obstruction (MVO), and intramyocardial hemorrhage (IMH), the latter presents an interesting clinical target. [1] Cardiovascular MRI has been shown capable of characterizing all of these tissue components. Other than MVO, which is currently detected by flow-deficient regions in contrast en...

To study the magnetic dynamics of superparamagnetic nanoparticles, we use scanning probe relaxometry and dephasing of the nitrogen vacancy (NV) center in diamond, characterizing the spin noise of a single 10 nm magnetite particle. Additionally, we show the anisotropy of the NV sensitivity's dependence on the applied decoherence measurement method. By comparing the change in relaxation (T1) and ...