Compelling evidence now suggests that alphabeta CD8 cytotoxic T lymphocytes (CTL) have an important role in preventing human immunodeficiency virus (HIV) infection and/or slowing progression to AIDS. Here, we describe an HIV type 1 CTL polyepitope, or polytope, vaccine comprising seven contiguous minimal HLA A2-restricted CD8 CTL epitopes conjoined in a single artificial construct. Epitope-spec...

A t − (n, k, ) design is a k-uniform hypergraph with the property that every set of t vertices is contained in exactly of the edges (blocks). A partial t − (n, k, ) design is a k-uniform hypergraph with the property that every set of t vertices is contained in at most edges; or equivalently the intersection of every set of + 1 blocks contains fewer than t elements. Let us denote by f (n, k, t) ...

This article focuses on web-based t&operation system design. We review current web-based t&robotic systems and identify human factors issues associated with them. Subsequently, the difficulties and challenges of interface design for web-based t&operation are analyzed from the perspectives of system implementation and human factors. A prototyped web-based system was developed to further explore ...

Digital s y s t e m s design and verif ication becomes m o r e dijgicult a s the s ize of t he s y s t e m grows. T o solve th,is problem, m a n y CAD tools have been developed, including s imu la t ion . However , as s y s t e m s increase in size and complexi ty , s imu la t ing the s y s t e m becomes v e r y costly, both in t i m e and space. For m o s t cases tha t u s e s imu la t ion , o...

Fault tolerance is a f u n d a m e n t a l technique f o r the a t ta inment of depen,dable computing. T h i s paper discusses a general paradigm for the design of faul t tolerant s y s t e m s and illustrates it by a design paradigm for faul t tolerant software.

Let C be an extremal Type III or IV code and $$D_{w}$$ the support design of for weight w. We introduce numbers, $$\delta (C)$$ s(C), as follows: is largest integer t such that, all weights, a t-design; s(C) denotes that w exists t-design. Herein, we consider possible values s(C).

A defining set of a t-(v,k,λ ) design is a subcollection of the block set of the design which is not contained in any other design with the same parameters. A defining set is said to be minimal if none of its proper subcollections is a defining set. A defining set is said to be smallest if no other defining set has a smaller cardinality. A t-(v,k,λ ) design D = (V,B) is called a full design if ...

A block design D = (V, B) is a set V of v elements together with a set B of b subsets of V called blocks, each containing exactly k elements, such that each element of V occurs in precisely r blocks, for some positive integers rand k. D is called a t-design if every t-subset of V occurs in exactly At blocks, for some positive integer At. Such a design D is described as a t-( v, k, At) design. A...