Introduction: Chimeric antigen receptor T cell therapy (CART) has emerged as an effective cell-based immunotherapy using patient-derived cells. Modified CAR cells are used for the treatment of relapsed or refractory (r/r) lymphoma with expression a CD19 specific receptor. CART prolongs survival patients r/r compared to historical controls. In currently ongoing phase III trials, response is asse...

This article concerns the stability and periodicity of solutions to the delay dynamic system x4(t) = A(t)x(t) + F (t, x(t), x(g(t))) + C(t) on a time scale. By the inequality technique for vectors, we obtain some stability criteria for the above system. Then, using the Horn fixed point theorem, we present some conditions under which our system is asymptotically periodic and its periodic solutio...

We analysed the clinical features of 82 patients with dominantly inherited ataxia in a cohort survey. All patients fulfilled the diagnostic criteria for Machado-Joseph disease. The mean age of onset of symptoms was 39.8 (+/- 12.5) years and the duration of the disease was 9.2 (+/- 6.7) years. Ataxia, peripheral neuropathy, and fasciculation scores correlated with age of onset and duration of di...

OBJECTIVE Impaired social functioning is a characteristic feature of schizophrenia. The aim of this study was to determine the factors that predict social functioning in schizophrenia. METHOD The study included 100 patients that met DSM-IV diagnostic criteria for schizophrenia. All the patients were evaluated using the Scale for the Assessment of Negative Symptoms, Scale for the Assessment of...

ments to the guidelines, but we believe changing the diagnostic criteria for CLL to 5.0 109/L B cells requires further study as the current recommendation will likely create more questions than answers. The real challenge is not to focus on numeric cutoffs, but to devise a classification system that recognizes a common clonal B-cell immunophenotype and reflects today’s genetic and biologic know...

BACKGROUND In Alzheimer's disease (AD) research patients are usually recruited from clinical practice, memory clinics or nursing homes. Lack of standardised inclusion and diagnostic criteria is a major concern in current AD studies. The aim of the study was to explore whether patient characteristics differ between study samples recruited from general practice and from a population based screeni...

BACKGROUND The extraction of teeth for orthodontic purpose has always been a controversial subject in the speciality. The aesthetics impact of the soft-tissue profile might play a key role in deciding on premolar extraction or non-extraction (NE) treatment, particularly in borderline patients. The purpose of this cephalometric study was to examine the soft-tissue treatment effects of Class II D...

Purposeful infection of healthy volunteers with a microbial pathogen seems at odds with acceptable ethical standards, but is an important contemporary research avenue used to study infectious diseases and their treatments. Generally termed ‘controlled human infection studies’, this research is particularly useful for fast tracking the development of candidate vaccines and may provide unique ins...

Abstract A hesitant fuzzy (HF) set is an extension of the sets and a T-spherical (T-SFS) generalization spherical (SFS). HF has significant role for modelling disagreements decision-makers over membership degree element. Also, T-SFS quite effective in uncertainty decision-making (DM) problems. In this paper, we define concept (HT-SF) (HT-SFS) by combining concepts T-SFS, present some set-theore...