Neoadjuvant (preoperative) systemic therapy is a good possibility for the treatment of symptomatic breast cancers of the locoregional stage. Chemotherapy or hormone therapy chosen according to the characteristics of the primary tumor, result in the regression of the tumor in the majority of the cases, favoring breast conserving surgery thereafter. The long-term effects of neoadjuvant systemic t...

stem cell-based therapy has great potential in treating health conditions including cardiovascular, autoimmune, type i diabetes, neurodegenerative and bone and cartilage diseases also in spinal cord injuries, malformations and cancer. in addition to their potential use to treat systemic diseases, stem cell-based therapy also provides a powerful tool to treat oral and dental diseases such as cra...

BACKGROUND The efficacy of systemic antineoplastic therapy on recurrent World Health Organization (WHO) grades II and III meningiomas is unclear. METHODS We performed a retrospective multicenter analysis of serial cranial MRI in patients with recurrent WHO II and III meningiomas treated with antineoplastic systemic therapies. Growth rates for tumor volume and diameter, as well as change rates...

Background: Systemic Lupus Erythematosus is a kind of multi-system autoimmune disorder with unknown aetiology and it produces antibodies against various tissues. Case Presentation:The patient wasa 44-year-old woman with a history of Systemic Lupus Erythematosus for approximately five years, along with underlying diseases including peptic ulcers, asthma, h...

Objective: We review the types, indications, and common regimens of systemic forms of therapy offered in early-stage breast cancer. We further detail the mechanism of action, approved uses, major toxicities, and relevance to breast reconstruction of specific agents. Methods: A review of the literature on PubMed and Cochrane databases was undertaken to define the indications and common regimens ...

The brain is one of the most frequent locations of metastasis in malignant melanoma. We aimed to identify prognostic factors for overall survival (OS) and local tumor control (LC) in patients with malignant melanoma metastasized to the brain treated by multimodal therapy. All patients diagnosed with malignant melanoma brain metastases between 1992 and 2011 at a single center were registered (n=...

BACKGROUND Electrochemotherapy (ECT) is an established procedure for treating breast cancer loco-regional recurrences following surgical intervention and/or radiotherapy. Limited information is available on ECT application as a concomitant procedure to systemic therapy in recurrent breast cancer. The primary objective of this study was to determine if the application of ECT in close temporal re...

Comparing effectiveness of cognitive-behavioral couple therapy with systemic- behavioral on intimacy and differentiation self in couples marital conflict

As women delay childbirth, the incidence of pregnancy-associated breast cancer is expected to increase. A high degree of suspicion is necessary to ensure timely investigation and diagnosis of breast cancer in a pregnant woman with a suspicious breast lump. Surgery as an initial approach is more suitable when diagnosis is made in the first trimester and systemic therapy can be delayed to second ...

OVERVIEW OF THE ISSUE The appropriate management of superficial and deep pyoderma requires the use of both topical and systemic therapy. Topical therapy is often used as an adjunctive to systemic antibiotics because it will speed the healing process, aid in the elimination of bacterial byproducts and generally make the patient feel better. Topical therapy can also be used as a preventative ther...