The autologous mixed lymphocyte reaction is impaired in patients with systemic lupus erythematosus. This is because nonthymus-derived (T)-lymphocyte preparations from such patients do not stimulate autologous T-lymphocyte proliferation normally. This defect may explain the impaired generation of suppressor activity in systemic lupus erythematosus and thereby the occurrence of autoantibodies in ...

Drug-induced hypersensitivity syndrome (DIHS) is a rare but severe life-threatening, drug-induced, systemic hypersensitivity reaction. We report two patients who developed DIHS during treatment for acute myeloid leukemia. Awareness of DIHS is necessary when systemic eruptions and high fever occur in leukemic patients, especially with rapid hematopoietic recovery after chemotherapies.

DTH: delayed hypersensitivity IV: intravenous RCM: radio contrast media SDRIFE: systemic drug-related intertriginous and flexural exanthema INTRODUCTION Systemic drug-related intertriginous and flexural exanthema (SDRIFE) is a cutaneous reaction, characterized by 5 diagnostic criteria (Table I). We report on 3 patients with SDRIFE induced by radio contrast media (RCM) and describe the dermatolo...

In a survey on work-related skin problems in professional ice hockey players one player developed a severe patch test reaction with an unexpected complication. The positive reaction to diethyl thiourea was vesiculo-bullous, oedematous and significantly elevated and a spreading several centimeters outside the test area was noted. Starting less than 24h after the patch test application, itching e...

paragangliomas are extra-adrenal counterparts of pheochromocytomas and are found at various anatomical sites such as the retroperitoneum, mediastinum, jugular foramen and carotid bifurcation, the latter two fonns being coined as chemodectomas. the vertebral column, especially the llullbar zone, is one of the rarest sites to be involved by paragangliomas. these lesions may have secretory functio...

introduction : due to the increased prevalence of medically compromised patients who require dental treatments, it is a crucial task for dentists and dental specialists to prepare themselves for emergent professional situations. this study was performed to determine the prevalence of different medical problems among a population of patients admitted to a dental educational center. materials and...

secondary systemic vasculitis and nonbacterial endocarditis are rare events. we report a case presented with different manifestations of underlying malignancy such as systemic vasculitis, non bacterial endocarditis and dic (disseminated intravascular coagulopathy). efforts to find the source of malignancy was unsuccessful and due to patient's unwillingness for further evaluation, finally under ...

BACKGROUND Cutaneous drug reactions are frequently found. Assessing the clinical and epidemiological profile of severe forms is extremely relevant for their better recognition and management. Few studies have assessed the severe forms of cutaneous drug reactions in patients hospitalized in our setting. OBJECTIVES To assess the clinical and epidemiological aspects of severe cutaneous adverse r...

OBJECTIVES We performed a prospective study to analyze mast cell mediators as predictors of systemic adverse reactions during rush venom-specific immunotherapy (VIT) in children. PATIENTS AND METHODS Nineteen children aged 5-17 years received VIT with Venomenhal (HALAllergy). We analyzed serum tryptase (CAP, Phadia), plasma prostaglandin (PG) D2 metabolites (9alpha, 11beta-PGF2), and urine PG...