In a disease with such widespread and variable manifestations as systemic lupus erythematosus the diagnosis, at least in the early stages, often depends upon a clinical suspicion supported by laboratory investigations, notably the demonstration of lupus erythematosus (L.E.) cells. While this test is highly specific for systemic lupus erythematosus it has these disadvantages. In a few patients L...

background: neonatal lupus erythematosus is an uncommon disease. congenital complete heart block (cchb) usually happens in neonates with maternal systemic lupus erythematosus. the most prevalent presentation of cchbis bradycardiathatcanbediagnosed through an electrocardiogram. case report: here in, we present the case of a full-term male neonate with gestational age of 37 weeks and birth weight...

BACKGROUND AND PURPOSE To determine factors associated with ischemic stroke and stroke severity in patients with systemic lupus erythematosus. METHODS Between 1992 and January 2005, 238 consecutive systemic lupus erythematosus patients with no history of stroke were followed-up longitudinally at the Maryland Lupus Clinic. Patients were monitored quarterly for a mean of 8 years after their sys...

OBJECTIVE We investigated ADAMTS13 (a disintegrin-like and metalloprotease with thrombospondin type 1 motif, member 13) messenger RNA levels as a biomarker of disease features in systemic lupus erythematosus. METHODS We measured and compared messenger RNA (mRNA) levels of ADAMTS13 in peripheral blood cells in patients with systemic lupus erythematosus and healthy control subjects by whole-gen...

Background & aim: Pregnant women with systemic lupus erythematosus (SLE) are considered to be at high risk regarding fetal complications and adverse outcomes. The aim of this study was to evaluate the fetal outcomes in pregnant women with the SLE. Methods: This retrospective study was conducted on a total of 125 patients with the SLE referred to the Clinic and Department of Rheumatology of Imam...

A case of Klinefelter's syndrome presenting with systemic lupus erythematosus while receiving androgen replacement therapy is described. The association of systemic lupus erythematosus with Klinefelter's syndrome is discussed, particularly in terms of the effect of sex hormones.

Secondary amyloidosis associated with systemic lupus erythematosus has rarely been reported. A 57-year-old female had been diagnosed as having possible systemic lupus erythematosus, although her clinical course was not typical. About one year after the diagnosis, treatment was begun with prednisolone because of progressive renal dysfunction, thrombocytopenia and low serum levels of complements....

Variability in systemic lupus erythematosus (SLE) disease manifestations is well recognized. Lupus disease activity can range from mild to severe. Fever is a common manifestation of SLE and occurs in 36%-86% of patients. In the Modified Systemic Lupus Erythematosus Disease Activity Index (M-SLEDAI), fever is taken into account as disease activity scoring. Assessment of lupus patients with fever...