نتایج جستجو برای: systemic cancers
تعداد نتایج: 264031 فیلتر نتایج به سال:
Although myelodysplastic syndromes have a clear definition in theory, the morphologic dysplasia associated with ineffective hematopoiesis may be subtle and difficult to recognize and can commonly be mimicked by systemic conditions, such as infections, autoimmune disorders, nutritional deficiencies, toxic factors and non-hematological malignancies. However, myelodysplastic syndromes may truly co...
Patients with cancer require effective treatment, including surgical resection, radiotherapy, and chemotherapy, but only a few options are available for the treatment of advanced cancer. Intensive drug exposure is fundamental to the eradication of cancers. However, adverse effects often prevent the administration of sufficient doses, resulting in poor antitumor responses [1]. Theoretically, iso...
Head and neck cancer (HNC) is the sixth most common malignancy worldwide. Despite recent advancements in surgical, chemotherapy, and radiation treatments, HNC remains a highly morbid and fatal disease. Unlike many other cancers, local control rather than systemic control is important for HNC survival. Therefore, novel local therapy in addition to systemic therapy is urgently needed. Oncolytic v...
MdmX, also known as Mdm4, is a critical negative regulator of p53, and its overexpression serves to block p53 tumor suppressor function in many cancers. Consequently, inhibiting MdmX has emerged as an attractive approach to restoring p53 function in those cancers that retain functional p53. However, the consequences of acute systemic MdmX inhibition in normal adult tissues remain unknown. To de...
UNLABELLED Despite evidence implicating transcription factors, including STAT3, in oncogenesis, these proteins have been regarded as "undruggable." We developed a decoy targeting STAT3 and conducted a phase 0 trial. Expression levels of STAT3 target genes were decreased in head and neck cancers following injection with the STAT3 decoy compared with tumors receiving saline control. Decoys have n...
OBJECTIVE Report on the 7-year experience with bilateral ophthalmic artery chemosurgery (OAC-Tandem therapy) for bilateral retinoblastoma. DESIGN Retrospective, single institution study. SUBJECTS 120 eyes of 60 children with bilateral retinoblastoma treated since March 2008. METHODS Retrospective review of all children treated at Memorial Sloan Kettering with bilateral ophthalmic artery c...
Objectives To investigate if patients with cutaneous lupus erythematosus (CLE) or systemic (SLE) have an increased risk of cancer compared the general population, and furthermore to identify specific types associated risk. Methods This is observational cohort study 5310 CLE SLE identified in Danish National Patient Register from 1 January 1995 31 December 2014. The was followed up for by linkag...
BACKGROUND Gastrointestinal cancers are among the leading causes of cancer-related deaths worldwide. In different tumor types, personalized systemic treatment strategies based upon biomarker-selection were established over the last years. Although there is a flood of targeted agents in clinical development, only a few targeted agents with a predictive biomarker could be established for the trea...
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